SOX2 is required independently in both stem and differentiated cells for pituitary tumorigenesis in

Animals Carcinogenesis / genetics Cell Lineage Cyclin-Dependent Kinase Inhibitor p27 / deficiency Endocrine Cells / metabolism Loss of Function Mutation MAP Kinase Signaling System Mice Mice, Inbred C57BL Neoplastic Stem Cells / metabolism Pituitary Neoplasms / genetics Protein Domains SOXB1 Transcription Factors / chemistry
pituitary stem cell tumorigenesis

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
16 02 2021
Historique:
entrez: 12 2 2021
pubmed: 13 2 2021
medline: 23 7 2021
Statut: ppublish

Résumé

P27, a cell cycle inhibitor, is also able to drive repression of

Identifiants

DOI: 10.1073/pnas.2017115118 PMID: 33574062 PMC: PMC7896314
pubmed: 33574062
pii: 2017115118
doi: 10.1073/pnas.2017115118
pmc: PMC7896314
pii:
doi:

Substances chimiques

SOXB1 Transcription Factors 0
Sox2 protein, mouse 0
Cyclin-Dependent Kinase Inhibitor p27 147604-94-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Wellcome Trust
ID : FC001107
Pays : United Kingdom
Organisme : Worldwide Cancer Research
ID : 13-1270
Pays : United Kingdom
Organisme : Medical Research Council
ID : U117562207
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : U117570590
Pays : United Kingdom
Organisme : Cancer Research UK
ID : FC001107
Pays : United Kingdom
Organisme : Medical Research Council
ID : U117512772
Pays : United Kingdom
Organisme : Medical Research Council
ID : FC001107
Pays : United Kingdom

Informations de copyright

Copyright © 2021 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

The authors declare no competing interest.

Références

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Auteurs

Veronica Moncho-Amor (V)

Laboratory of Stem Cell Biology and Developmental Genetics, The Francis Crick Institute, NW1 1AT London, United Kingdom.

Probir Chakravarty (P)

Bioinformatics Core, The Francis Crick Institute, NW1 1AT London, United Kingdom.

Christophe Galichet (C)

Laboratory of Stem Cell Biology and Developmental Genetics, The Francis Crick Institute, NW1 1AT London, United Kingdom.
ORCID: 0000-0003-0244-9381

Ander Matheu (A)

Cellular Oncology Group, Biodonostia Health Research Institute, E-20014 San Sebastian, Spain.
CIBER de Fragilidad y Envejecimiento Saludable (CIBERfes), 28029 Madrid, Spain.
IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain.

Robin Lovell-Badge (R)

Laboratory of Stem Cell Biology and Developmental Genetics, The Francis Crick Institute, NW1 1AT London, United Kingdom; robin.lovell-badge@crick.ac.uk karine.rizzoti@crick.ac.uk.
ORCID: 0000-0001-9364-4179

Karine Rizzoti (K)

Laboratory of Stem Cell Biology and Developmental Genetics, The Francis Crick Institute, NW1 1AT London, United Kingdom; robin.lovell-badge@crick.ac.uk karine.rizzoti@crick.ac.uk.
ORCID: 0000-0003-0711-5452

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › SOX2 is required independently in both stem...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › SOX2 is required independently in both stem...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Lignage cellulaire › SOX2 is required independently in both stem...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Protéines inhibitrices des kinases cyclines-dépendantes › Inhibiteur p27 de kinase cycline-dépendante › SOX2 is required independently in both stem...
questionsmedicales.fr › Cellules › Cellules endocrines › SOX2 is required independently in both stem...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation perte de fonction › SOX2 is required independently in both stem...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Système de signalisation des MAP kinases › SOX2 is required independently in both stem...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › SOX2 is required independently in both stem...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › SOX2 is required independently in both stem...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches tumorales › SOX2 is required independently in both stem...
questionsmedicales.fr › Maladies endocriniennes › Maladies de l'hypophyse › Tumeurs de l'hypophyse › SOX2 is required independently in both stem...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Domaines protéiques › SOX2 is required independently in both stem...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription SOX › Facteurs de transcription SOX-B1 › SOX2 is required independently in both stem...