Obstructive sleep apnoea increases lipolysis and deteriorates glucose homeostasis in patients with type 2 diabetes mellitus.
Adipose Tissue
/ drug effects
Aged
Diabetes Mellitus, Type 2
/ complications
Epinephrine
/ administration & dosage
Female
Glucose
/ metabolism
Homeostasis
/ physiology
Humans
Insulin
/ metabolism
Insulin Resistance
/ physiology
Isoproterenol
/ administration & dosage
Lipolysis
/ drug effects
Male
Middle Aged
Sleep Apnea, Obstructive
/ complications
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 02 2021
11 02 2021
Historique:
received:
07
06
2020
accepted:
25
01
2021
entrez:
12
2
2021
pubmed:
13
2
2021
medline:
16
11
2021
Statut:
epublish
Résumé
Obstructive sleep apnoea (OSA) is associated with type 2 diabetes mellitus (T2DM). However, mechanisms mediating association between these two conditions remain unclear. This study investigated, whether the OSA-associated changes in adipose tissue lipolysis might contribute to impaired glucose homeostasis in patient with T2DM. Thirty-five matched subjects were recruited into three groups: T2DM + severe OSA (T2DM + OSA, n = 11), T2DM with mild/no OSA (T2DM, n = 10) and healthy controls (n = 14). Subcutaneous abdominal adipose tissue microdialysis assessed spontaneous, epinephrine- and isoprenaline-stimulated lipolysis. Glucose metabolism was assessed by intravenous glucose tolerance test. Spontaneous lipolysis was higher in the T2DM + OSA compared with the T2DM (60.34 ± 23.40 vs. 42.53 ± 10.16 μmol/L, p = 0.013), as well as epinephrine-stimulated lipolysis (236.84 ± 103.90 vs. 167.39 ± 52.17 µmol/L, p < 0.001). Isoprenaline-stimulated lipolysis was unaffected by the presence of OSA (p = 0.750). The α
Identifiants
pubmed: 33574418
doi: 10.1038/s41598-021-83018-1
pii: 10.1038/s41598-021-83018-1
pmc: PMC7878919
doi:
Substances chimiques
Insulin
0
Glucose
IY9XDZ35W2
Isoproterenol
L628TT009W
Epinephrine
YKH834O4BH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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