Targeting the 5' untranslated region of

5′ UTR SMN2 antisense oligonucleotides spinal muscular atrophy

Journal

Molecular therapy. Nucleic acids
ISSN: 2162-2531
Titre abrégé: Mol Ther Nucleic Acids
Pays: United States
ID NLM: 101581621

Informations de publication

Date de publication:
05 Mar 2021
Historique:
received: 22 07 2020
accepted: 30 12 2020
entrez: 12 2 2021
pubmed: 13 2 2021
medline: 13 2 2021
Statut: epublish

Résumé

Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by mutations in the survival motor neuron 1 (

Identifiants

pubmed: 33575118
doi: 10.1016/j.omtn.2020.12.027
pii: S2162-2531(20)30408-X
pmc: PMC7851419
doi:

Types de publication

Journal Article

Langues

eng

Pagination

731-742

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 205162/Z/16/Z
Pays : United Kingdom

Déclaration de conflit d'intérêts

A patent application was filed for the 5′ UTR ASOs described in this manuscript. M.J.W. is a founder of and shareholder in PepGen.

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Auteurs

Audrey M Winkelsas (AM)

Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.

Christopher Grunseich (C)

Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

George G Harmison (GG)

Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

Katarzyna Chwalenia (K)

Department of Paediatrics, University of Oxford, Oxford OX1 3QX, UK.

Carlo Rinaldi (C)

Department of Paediatrics, University of Oxford, Oxford OX1 3QX, UK.

Suzan M Hammond (SM)

Department of Paediatrics, University of Oxford, Oxford OX1 3QX, UK.

Kory Johnson (K)

Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

Melissa Bowerman (M)

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.

Sukrat Arya (S)

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.

Kevin Talbot (K)

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.

Matthew J Wood (MJ)

Department of Paediatrics, University of Oxford, Oxford OX1 3QX, UK.

Kenneth H Fischbeck (KH)

Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

Classifications MeSH