Non-coding RNAs: Emerging from the discovery to therapeutic applications.
Biological activity
Diagnosis
Therapeutic application
ncRNA
Journal
Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
30
11
2020
revised:
03
02
2021
accepted:
04
02
2021
pubmed:
13
2
2021
medline:
14
9
2021
entrez:
12
2
2021
Statut:
ppublish
Résumé
The knowledge about non-coding RNAs (ncRNAs) is rapidly increasing with new data continuously emerging, regarding their diverse types, applications, and roles. Particular attention has been given to ncRNA with regulatory functions, which may have a critical role both in biological and pathological conditions. As a result of the diversity of ncRNAs and their ubiquitous involvement in several biologic processes, ncRNA started to be considered in the biomedical field, with immense potential to be exploited either as biomarkers or as therapeutic agents in certain pathologies. Indeed, ncRNA-based therapeutics have been proposed in many disorders and some even reached clinical trials. However, to prepare an RNA product suitable for pharmacological applications, certain criteria must be fulfilled, and it has to be guaranteed RNA purity, stability, and bioactivity. So, in this review, the different types of ncRNAs are identified and characterized, by describing their biogenesis, functions, and applications. A perspective on the main challenges and innovative approaches for the future and broad therapeutic application of RNA is also presented.
Identifiants
pubmed: 33577888
pii: S0006-2952(21)00065-4
doi: 10.1016/j.bcp.2021.114469
pii:
doi:
Substances chimiques
RNA, Untranslated
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
114469Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.