Gouania willdenowi is a teleost fish without immunoglobulin genes.
Animals
B-Lymphocytes
/ immunology
CD79 Antigens
/ immunology
Fishes
/ genetics
Genes, Immunoglobulin
/ genetics
Genome
/ genetics
Immunoglobulins
/ genetics
Receptors, Antigen, B-Cell
/ genetics
Receptors, Antigen, T-Cell, gamma-delta
/ immunology
T-Lymphocytes
/ immunology
Transcriptome
/ genetics
B cell receptor
Gobiesocidae
Immunoglobulins
Journal
Molecular immunology
ISSN: 1872-9142
Titre abrégé: Mol Immunol
Pays: England
ID NLM: 7905289
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
09
11
2020
revised:
15
01
2021
accepted:
19
01
2021
pubmed:
13
2
2021
medline:
24
4
2021
entrez:
12
2
2021
Statut:
ppublish
Résumé
Immunoglobulin (Ig) genes encode antibodies in jawed vertebrates. They are essential elements of the adaptive immune response. Ig exists in soluble form or as part of the B cell membrane antigen receptor (BCR). Studies of Ig genes in fish genomes reveal the absence of Ig genes in Gouania willdenowi by deletion of the entire Ig locus from the canonical chromosomal region. The genes coding for integral BCR proteins, CD79a and CD79b, are also absent. Genes exist for T α/β lymphocyte receptors but not for the T γ/δ receptors. The results of the genomic analysis are independently corroborated with RNA-Seq transcriptomes from other Gobiesocidae species. From the transcriptome studies, Ig is also absent from these other Gobiesocidae species, Acyrtus sp. and Tomicodon sp. Present evidence suggests that Ig is missing from all species of the Gobiesocidae family.
Identifiants
pubmed: 33578305
pii: S0161-5890(21)00030-4
doi: 10.1016/j.molimm.2021.01.022
pii:
doi:
Substances chimiques
CD79 Antigens
0
Immunoglobulins
0
Receptors, Antigen, B-Cell
0
Receptors, Antigen, T-Cell, gamma-delta
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102-107Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.