Sucralose and Cardiometabolic Health: Current Understanding from Receptors to Clinical Investigations.
cardiovascular health
glucose metabolism
low-calorie sweetener
sucralose
sweet and bitter taste receptor
taste signaling cascade
Journal
Advances in nutrition (Bethesda, Md.)
ISSN: 2156-5376
Titre abrégé: Adv Nutr
Pays: United States
ID NLM: 101540874
Informations de publication
Date de publication:
30 07 2021
30 07 2021
Historique:
received:
27
08
2020
revised:
26
10
2020
accepted:
31
12
2020
pubmed:
13
2
2021
medline:
19
8
2021
entrez:
12
2
2021
Statut:
ppublish
Résumé
The excess consumption of added sugar is consistently found to be associated with weight gain, and a higher risk of type 2 diabetes mellitus, coronary heart disease, and stroke. In an effort to reduce the risk of cardiometabolic disease, sugar is frequently replaced by low- and null-calorie sweeteners (LCSs). Alarmingly, though, emerging evidence indicates that the consumption of LCSs is associated with an increase in cardiovascular mortality risk that is amplified in those who are overweight or obese. Sucralose, a null-caloric high-intensity sweetener, is the most commonly used LCS worldwide, which is regularly consumed by healthy individuals and patients with metabolic disease. To explore a potential causal role for sucralose in increased cardiovascular risk, this present review summarizes the preclinical and clinical data from current research detailing the effects of sucralose on systems controlling food intake, glucose homeostasis, and gut microbiota.
Identifiants
pubmed: 33578411
pii: S2161-8313(22)00152-1
doi: 10.1093/advances/nmaa185
pmc: PMC8321845
doi:
Substances chimiques
Non-Nutritive Sweeteners
0
Sucrose
57-50-1
trichlorosucrose
96K6UQ3ZD4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1500-1513Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.
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