Remodeling of Neurotransmission, Chemokine, and PI3K-AKT Signaling Genomic Fabrics in Neuropsychiatric Systemic Lupus Erythematosus.


Journal

Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097

Informations de publication

Date de publication:
10 02 2021
Historique:
received: 11 01 2021
revised: 05 02 2021
accepted: 05 02 2021
entrez: 13 2 2021
pubmed: 14 2 2021
medline: 24 7 2021
Statut: epublish

Résumé

Cognitive dysfunction and mood changes are prevalent and especially taxing issues for patients with systemic lupus erythematosus (SLE). Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) and its cognate receptor Fn14 have been shown to play an important role in neurocognitive dysfunction in murine lupus. We profiled and compared gene expression in the cortices of MRL/+, MRL/

Identifiants

pubmed: 33578738
pii: genes12020251
doi: 10.3390/genes12020251
pmc: PMC7916450
pii:
doi:

Substances chimiques

Chemokines 0
Cytokine TWEAK 0
TWEAK Receptor 0
Tnfrsf12a protein, mouse 0
Tnfsf12 protein, mouse 0
Proto-Oncogene Proteins c-akt EC 2.7.11.1
Adenylyl Cyclases EC 4.6.1.1
adenylate cyclase 3 EC 4.6.1.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NICHD NIH HHS
ID : P50 HD105352
Pays : United States

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Auteurs

Dumitru Iacobas (D)

Center for Computational Systems Biology, Personalized Genomics Laboratory, Roy G. Perry College of Engineering, Prairie View A & M University, Prairie View, TX 77446, USA.
DP Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Jing Wen (J)

Department of Medicine (Rheumatology), Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Sanda Iacobas (S)

Department of Pathology, New York Medical College, Valhalla, NY 10595, USA.

Noa Schwartz (N)

Department of Medicine (Rheumatology), Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Chaim Putterman (C)

Department of Medicine (Rheumatology), Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Azrieli Faculty of Medicine, Bar-Ilan University, Zefat 52100, Israel.
Galilee Medical Center, Research Institute, Nahariya 22100, Israel.

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Classifications MeSH