HPMA Copolymer-Based Nanomedicines in Controlled Drug Delivery.
EPR effect
HPMA copolymers
controlled release
drug delivery
nanomedicines
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
10 Feb 2021
10 Feb 2021
Historique:
received:
18
01
2021
revised:
05
02
2021
accepted:
08
02
2021
entrez:
13
2
2021
pubmed:
14
2
2021
medline:
14
2
2021
Statut:
epublish
Résumé
Recently, numerous polymer materials have been employed as drug carrier systems in medicinal research, and their detailed properties have been thoroughly evaluated. Water-soluble polymer carriers play a significant role between these studied polymer systems as they are advantageously applied as carriers of low-molecular-weight drugs and compounds, e.g., cytostatic agents, anti-inflammatory drugs, antimicrobial molecules, or multidrug resistance inhibitors. Covalent attachment of carried molecules using a biodegradable spacer is strongly preferred, as such design ensures the controlled release of the drug in the place of a desired pharmacological effect in a reasonable time-dependent manner. Importantly, the synthetic polymer biomaterials based on
Identifiants
pubmed: 33578756
pii: jpm11020115
doi: 10.3390/jpm11020115
pmc: PMC7916469
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Grantová Agentura České Republiky
ID : 20-04790S
Organisme : Ministerstvo Zdravotnictví Ceské Republiky
ID : NU20-08-00255
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