Effects of a Lifestyle Change Intervention on Semen Quality in Healthy Young Men Living in Highly Polluted Areas in Italy: The FASt Randomized Controlled Trial.
Dietary habits
Lifestyle intervention
Male fertility
Mediterranean diet
Physical activity
Pollution
Semen quality
Journal
European urology focus
ISSN: 2405-4569
Titre abrégé: Eur Urol Focus
Pays: Netherlands
ID NLM: 101665661
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
25
09
2020
revised:
24
12
2020
accepted:
25
01
2021
pubmed:
14
2
2021
medline:
15
4
2022
entrez:
13
2
2021
Statut:
ppublish
Résumé
Human semen quality is affected by lifestyle and environmental factors. To evaluate the short-term effects of a diet and physical activity intervention on semen quality of healthy young men living in highly polluted areas of Italy. A randomized controlled trial was conducted. Healthy young men were assigned to an intervention or a control group. A 4-mo Mediterranean diet and moderate physical activity program. The primary outcomes were sperm concentration, motility and morphology, concentration of round cells, and semen total antioxidant capacity. Secondary outcomes were adherence to Mediterranean diet and physical activity. All outcomes were measured twice, at the enrollment (t0) and at the end of the intervention (t4). A total of 263 individuals attended all visits, and underwent examinations and laboratory analyses: 137 in the intervention group and 126 in the control group. The adherence to Mediterranean diet and physical activity level increased more in the intervention group than in the control group from t0 to t4. Sperm concentration, total and progressive motility, and proportion of normal morphology cells increased in the intervention group but decreased in the control group, with statistically significant differences between the two groups at t4. The total antioxidant capacity increased in the intervention group but decreased in the control group, from t0 to t4. Study results showed that an intervention based on Mediterranean diet and regular physical activity can determine an improvement of semen quality in healthy young men. Our study aimed to evaluate the effect of a lifestyle intervention on semen quality of healthy young men. We assigned the 263 enrolled individuals to an intervention or a control group. The intervention group followed a 4-mo Mediterranean diet and moderate physical activity program, at the end of which the participants showed an improvement of semen quality parameters.
Sections du résumé
BACKGROUND
BACKGROUND
Human semen quality is affected by lifestyle and environmental factors.
OBJECTIVE
OBJECTIVE
To evaluate the short-term effects of a diet and physical activity intervention on semen quality of healthy young men living in highly polluted areas of Italy.
DESIGN, SETTING, AND PARTICIPANTS
METHODS
A randomized controlled trial was conducted. Healthy young men were assigned to an intervention or a control group.
INTERVENTION
METHODS
A 4-mo Mediterranean diet and moderate physical activity program.
OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS
METHODS
The primary outcomes were sperm concentration, motility and morphology, concentration of round cells, and semen total antioxidant capacity. Secondary outcomes were adherence to Mediterranean diet and physical activity. All outcomes were measured twice, at the enrollment (t0) and at the end of the intervention (t4).
RESULTS AND LIMITATIONS
CONCLUSIONS
A total of 263 individuals attended all visits, and underwent examinations and laboratory analyses: 137 in the intervention group and 126 in the control group. The adherence to Mediterranean diet and physical activity level increased more in the intervention group than in the control group from t0 to t4. Sperm concentration, total and progressive motility, and proportion of normal morphology cells increased in the intervention group but decreased in the control group, with statistically significant differences between the two groups at t4. The total antioxidant capacity increased in the intervention group but decreased in the control group, from t0 to t4.
CONCLUSIONS
CONCLUSIONS
Study results showed that an intervention based on Mediterranean diet and regular physical activity can determine an improvement of semen quality in healthy young men.
PATIENT SUMMARY
RESULTS
Our study aimed to evaluate the effect of a lifestyle intervention on semen quality of healthy young men. We assigned the 263 enrolled individuals to an intervention or a control group. The intervention group followed a 4-mo Mediterranean diet and moderate physical activity program, at the end of which the participants showed an improvement of semen quality parameters.
Identifiants
pubmed: 33579652
pii: S2405-4569(21)00041-9
doi: 10.1016/j.euf.2021.01.017
pii:
doi:
Substances chimiques
Antioxidants
0
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
351-359Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.