Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study.

Adult Antibodies, Viral / blood Bayes Theorem COVID-19 / diagnosis COVID-19 Serological Testing Cohort Studies Cross-Sectional Studies Female Health Personnel Humans Los Angeles / epidemiology Male Middle Aged SARS-CoV-2 / immunology Seroepidemiologic Studies
COVID-19 infectious diseases public health

Journal

BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874

Informations de publication

Date de publication:
12 02 2021
Historique:
entrez: 13 2 2021
pubmed: 14 2 2021
medline: 26 2 2021
Statut: epublish

Résumé

We sought to determine the extent of SARS-CoV-2 seroprevalence and the factors associated with seroprevalence across a diverse cohort of healthcare workers. Observational cohort study of healthcare workers, including SARS-CoV-2 serology testing and participant questionnaires. A multisite healthcare delivery system located in Los Angeles County. A diverse and unselected population of adults (n=6062) employed in a multisite healthcare delivery system located in Los Angeles County, including individuals with direct patient contact and others with non-patient-oriented work functions. Using Bayesian and multivariate analyses, we estimated seroprevalence and factors associated with seropositivity and antibody levels, including pre-existing demographic and clinical characteristics; potential COVID-19 illness-related exposures; and symptoms consistent with COVID-19 infection. We observed a seroprevalence rate of 4.1%, with anosmia as the most prominently associated self-reported symptom (OR 11.04, p<0.001) in addition to fever (OR 2.02, p=0.002) and myalgias (OR 1.65, p=0.035). After adjusting for potential confounders, seroprevalence was also associated with Hispanic ethnicity (OR 1.98, p=0.001) and African-American race (OR 2.02, p=0.027) as well as contact with a COVID-19-diagnosed individual in the household (OR 5.73, p<0.001) or clinical work setting (OR 1.76, p=0.002). Importantly, African-American race and Hispanic ethnicity were associated with antibody positivity even after adjusting for personal COVID-19 diagnosis status, suggesting the contribution of unmeasured structural or societal factors. The demographic factors associated with SARS-CoV-2 seroprevalence among our healthcare workers underscore the importance of exposure sources beyond the workplace. The size and diversity of our study population, combined with robust survey and modelling techniques, provide a vibrant picture of the demographic factors, exposures and symptoms that can identify individuals with susceptibility as well as potential to mount an immune response to COVID-19.

Identifiants

DOI: 10.1136/bmjopen-2020-043584 PMID: 33579769 PMC: PMC7883610
pubmed: 33579769
pii: bmjopen-2020-043584
doi: 10.1136/bmjopen-2020-043584
pmc: PMC7883610
doi:

Substances chimiques

Antibodies, Viral 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e043584

Subventions

Organisme : NCI NIH HHS
ID : U54 CA260591
Pays : United States

Informations de copyright

© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

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Auteurs

Joseph E Ebinger (JE)

Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Gregory J Botwin (GJ)

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Christine M Albert (CM)

Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Mona Alotaibi (M)

Division of Pulmonary and Critical Care Medicine, University of California, San Diego, La Jolla, California, USA.

Moshe Arditi (M)

Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Departments of Pediatrics, Division of Infectious Diseases and Immunology, and Infectious and Immunologic Diseases Research Center (IIDRC), Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

Anders H Berg (AH)

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Aleksandra Binek (A)

Advanced Clinical Biosystems Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Patrick Botting (P)

Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Justyna Fert-Bober (J)

Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Jane C Figueiredo (JC)

Cedars-Sinai Cancer and Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Jonathan D Grein (JD)

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Department of Epidemiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Wohaib Hasan (W)

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Biobank & Translational Research Core Laboratory, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Mir Henglin (M)

Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Shehnaz K Hussain (SK)

Department of Public Health Sciences and Comprehensive Cancer Center, University of California, Davis, Davis, California, USA.

Mohit Jain (M)

Department of Medicine and Pharmacology, University of California, San Diego, La Jolla, California, USA.

Sandy Joung (S)

Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Michael Karin (M)

Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, California, USA.

Elizabeth H Kim (EH)

Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Dalin Li (D)

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Yunxian Liu (Y)

Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Eric Luong (E)

Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Dermot P B McGovern (DPB)

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Akil Merchant (A)

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Noah Merin (N)

Department of Internal Medicine, Division of Hematology, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Peggy B Miles (PB)

Employee Health Services, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Margo Minissian (M)

Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Brawerman Nursing Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Trevor Trung Nguyen (TT)

Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Koen Raedschelders (K)

Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Advanced Clinical Biosystems Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Mohamad A Rashid (MA)

Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Celine E Riera (CE)

Center for Neural Science and Medicine, Department of Biomedical Sciences, Board of Governors Regenerative Medicine Institute, Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.

Richard V Riggs (RV)

Chief Medical Officer, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Sonia Sharma (S)

La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.

Sarah Sternbach (S)

Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Nancy Sun (N)

Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Warren G Tourtellotte (WG)

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Biobank & Translational Research Core Laboratory, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Jennifer E Van Eyk (JE)

Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Advanced Clinical Biosystems Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Barbra Streisand Women's Heart Center, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Kimia Sobhani (K)

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA susan.cheng@cshs.org Jonathan.Braun2@cshs.org Kimia.Sobhani@cshs.org.

Jonathan G Braun (JG)

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA susan.cheng@cshs.org Jonathan.Braun2@cshs.org Kimia.Sobhani@cshs.org.

Susan Cheng (S)

Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA susan.cheng@cshs.org Jonathan.Braun2@cshs.org Kimia.Sobhani@cshs.org.
Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Barbra Streisand Women's Heart Center, Cedars-Sinai Medical Center, Los Angeles, California, USA.
ORCID: 0000-0002-4977-036X

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Seroprevalence of antibodies to SARS-CoV-2 in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Seroprevalence of antibodies to SARS-CoV-2 in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Théorème de Bayes › Seroprevalence of antibodies to SARS-CoV-2 in...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Seroprevalence of antibodies to SARS-CoV-2 in...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Tests sérologiques › Dépistage sérologique de la COVID-19 › Seroprevalence of antibodies to SARS-CoV-2 in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Seroprevalence of antibodies to SARS-CoV-2 in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Seroprevalence of antibodies to SARS-CoV-2 in...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Personnel de santé › Seroprevalence of antibodies to SARS-CoV-2 in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Seroprevalence of antibodies to SARS-CoV-2 in...
questionsmedicales.fr › Régions géographiques › Villes › Los Angeles › Seroprevalence of antibodies to SARS-CoV-2 in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Seroprevalence of antibodies to SARS-CoV-2 in...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Seroprevalence of antibodies to SARS-CoV-2 in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études séroépidémiologiques › Seroprevalence of antibodies to SARS-CoV-2 in...