Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
12 02 2021
12 02 2021
Historique:
received:
30
06
2020
accepted:
08
01
2021
entrez:
13
2
2021
pubmed:
14
2
2021
medline:
3
3
2021
Statut:
epublish
Résumé
Both the perivascular niche (PVN) and the integration into multicellular networks by tumor microtubes (TMs) have been associated with progression and resistance to therapies in glioblastoma, but their specific contribution remained unknown. By long-term tracking of tumor cell fate and dynamics in the live mouse brain, differential therapeutic responses in both niches are determined. Both the PVN, a preferential location of long-term quiescent glioma cells, and network integration facilitate resistance against cytotoxic effects of radiotherapy and chemotherapy-independently of each other, but with additive effects. Perivascular glioblastoma cells are particularly able to actively repair damage to tumor regions. Population of the PVN and resistance in it depend on proficient NOTCH1 expression. In turn, NOTCH1 downregulation induces resistant multicellular networks by TM extension. Our findings identify NOTCH1 as a central switch between the PVN and network niche in glioma, and demonstrate robust cross-compensation when only one niche is targeted.
Identifiants
pubmed: 33579922
doi: 10.1038/s41467-021-21117-3
pii: 10.1038/s41467-021-21117-3
pmc: PMC7881116
doi:
Substances chimiques
Notch1 protein, mouse
0
Receptor, Notch1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1014Références
Neuroscience. 1999;93(2):433-9
pubmed: 10465425
Int J Cancer. 2011 Aug 1;129(3):659-70
pubmed: 21425258
Clin Cancer Res. 2016 Oct 1;22(19):4786-4796
pubmed: 27154916
Sci Rep. 2017 Aug 8;7(1):7529
pubmed: 28790339
Nature. 2018 Aug;560(7717):243-247
pubmed: 30069053
Glia. 2002 Sep;39(3):193-206
pubmed: 12203386
Nat Med. 2002 Sep;8(9):963-70
pubmed: 12161747
Bioinformatics. 2015 Jan 15;31(2):166-9
pubmed: 25260700
Arch Neurol. 2012 Apr;69(4):523-6
pubmed: 22158715
Cell Stem Cell. 2011 May 6;8(5):482-5
pubmed: 21549324
Brain Pathol. 2010 Jan;20(1):245-54
pubmed: 19903171
Acta Neuropathol. 2018 Aug;136(2):181-210
pubmed: 29967940
Nature. 2012 Aug 23;488(7412):522-6
pubmed: 22854781
Nat Neurosci. 2011 Oct 26;14(11):1375-81
pubmed: 22030548
Stem Cells. 2010 Jan;28(1):17-28
pubmed: 19921751
Cell Stem Cell. 2010 Feb 5;6(2):141-52
pubmed: 20144787
Acta Neuropathol. 2012 Oct;124(4):547-60
pubmed: 22810491
Brain Pathol. 2003 Apr;13(2):133-43
pubmed: 12744467
PLoS One. 2017 Aug 3;12(8):e0182183
pubmed: 28771552
Nat Commun. 2019 Dec 13;10(1):5704
pubmed: 31836713
Nat Rev Dis Primers. 2015 Jul 16;1:15017
pubmed: 27188790
Cancer Res. 2011 Sep 15;71(18):6061-72
pubmed: 21788346
Dev Cell. 2015 Feb 23;32(4):435-46
pubmed: 25710530
Sci Rep. 2019 Feb 14;9(1):2054
pubmed: 30765850
Nature. 2019 Sep;573(7775):532-538
pubmed: 31534219
Genome Biol. 2014;15(12):550
pubmed: 25516281
Science. 1999 Oct 22;286(5440):741-6
pubmed: 10531053
Cancer Res. 2003 Sep 15;63(18):5821-8
pubmed: 14522905
Cell Metab. 2019 Jul 2;30(1):201-211.e6
pubmed: 31056286
Cancers (Basel). 2019 Mar 01;11(3):
pubmed: 30832246
Int J Cancer. 2020 Dec 15;147(12):3281-3291
pubmed: 32510582
Nat Biotechnol. 2020 Feb;38(2):115-117
pubmed: 32034389
Hum Pathol. 2015 Jan;46(1):120-8
pubmed: 25455996
Cancer Discov. 2019 Dec;9(12):1708-1719
pubmed: 31554641
Cells. 2020 Oct 15;9(10):
pubmed: 33076453
Cold Spring Harb Symp Quant Biol. 2008;73:357-65
pubmed: 19022766
Cancer Cell. 2007 Jan;11(1):69-82
pubmed: 17222791
Oncotarget. 2016 Jul 5;7(27):41251-41264
pubmed: 27183910
Sci Rep. 2017 Dec 4;7(1):16878
pubmed: 29203879
Nature. 2015 Dec 3;528(7580):93-8
pubmed: 26536111
Nature. 2018 Mar 22;555(7697):469-474
pubmed: 29539639
Nat Rev Neurosci. 2011 Feb;12(2):88-104
pubmed: 21248788
Mol Cell. 2010 May 28;38(4):576-89
pubmed: 20513432
Oncotarget. 2017 Sep 30;8(50):88059-88068
pubmed: 29152141
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Nat Neurosci. 2019 Dec;22(12):1951-1960
pubmed: 31719671
Nature. 2019 Sep;573(7775):539-545
pubmed: 31534222
Cell Cycle. 2010 Aug 1;9(15):3012-21
pubmed: 20714216
Nat Med. 2019 Mar;25(3):367-376
pubmed: 30842674
J Clin Oncol. 2003 Apr 15;21(8):1624-36
pubmed: 12697889
Nat Commun. 2020 Jan 28;11(1):550
pubmed: 31992716
Nat Rev Cancer. 2007 Oct;7(10):733-6
pubmed: 17882276
PLoS One. 2011;6(9):e24807
pubmed: 21961046
J Neurosurg. 1996 Dec;85(6):1078-84
pubmed: 8929498
Cancer. 2012 Sep 1;118(17):4201-11
pubmed: 22294349
Front Oncol. 2015 Jan 05;4:341
pubmed: 25601901
Cancer Med. 2020 Nov;9(22):8373-8385
pubmed: 32991787
Oncotarget. 2017 Jan 31;8(5):8283-8293
pubmed: 28030818
Neuro Oncol. 2017 Oct 1;19(10):1316-1326
pubmed: 28419303
Cancer Res. 2004 Oct 1;64(19):7011-21
pubmed: 15466194
Int J Cancer. 2012 Sep 15;131(6):1342-50
pubmed: 22139906
Neuro Oncol. 2020 Dec 15;:
pubmed: 33320195
Oncotarget. 2017 May 23;8(39):64932-64953
pubmed: 29029402
World Neurosurg. 2019 Nov;131:252-263.e2
pubmed: 31376551
J Neurosci. 2017 Jul 19;37(29):6837-6850
pubmed: 28607172
Neuro Oncol. 2016 Apr;18(4):479-85
pubmed: 26995789
Genes Dev. 2015 Jun 15;29(12):1203-17
pubmed: 26109046
Cell Death Dis. 2018 Feb 6;9(2):158
pubmed: 29410396