Magneto-optical diagnosis of symptomatic malaria in Papua New Guinea.
Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Diagnostic Tests, Routine
/ methods
Female
Hemeproteins
Humans
Malaria
/ diagnosis
Malaria, Vivax
/ diagnosis
Male
Microscopy
/ methods
Middle Aged
Optical Devices
Papua New Guinea
Plasmodium vivax
/ genetics
Polymerase Chain Reaction
/ methods
Sensitivity and Specificity
Young Adult
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
12 02 2021
12 02 2021
Historique:
received:
17
06
2020
accepted:
07
01
2021
entrez:
13
2
2021
pubmed:
14
2
2021
medline:
3
3
2021
Statut:
epublish
Résumé
Improved methods for malaria diagnosis are urgently needed. Here, we evaluate a novel method named rotating-crystal magneto-optical detection (RMOD) in 956 suspected malaria patients in Papua New Guinea. RMOD tests can be conducted within minutes and at low cost. We systematically evaluate the capability of RMOD to detect infections by directly comparing it with expert light microscopy, rapid diagnostic tests and polymerase chain reaction on capillary blood samples. We show that compared to light microscopy, RMOD exhibits 82% sensitivity and 84% specificity to detect any malaria infection and 87% sensitivity and 88% specificity to detect Plasmodium vivax. This indicates that RMOD could be useful in P. vivax dominated elimination settings. Parasite density correlates well with the quantitative magneto-optical signal. Importantly, residual hemozoin present in malaria-negative patients is also detectable by RMOD, indicating its ability to detect previous infections. This could be exploited to reveal transmission hotspots in low-transmission settings.
Identifiants
pubmed: 33579923
doi: 10.1038/s41467-021-21110-w
pii: 10.1038/s41467-021-21110-w
pmc: PMC7881035
doi:
Substances chimiques
Hemeproteins
0
hemozoin
39404-00-7
Banques de données
figshare
['10.6084/m9.figshare.13078181.v1']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
969Références
Br Med J. 1897 Dec 18;2(1929):1786-8
pubmed: 20757493
Malar J. 2009 May 11;8:98
pubmed: 19432971
J Clin Microbiol. 2014 Sep;52(9):3303-9
pubmed: 24989601
Trans R Soc Trop Med Hyg. 1989 Mar-Apr;83(2):167-72
pubmed: 2692224
PLoS Med. 2011 Jan 25;8(1):e1000396
pubmed: 21311583
Lancet. 2010 Nov 6;376(9752):1517-21
pubmed: 21035844
Malar J. 2010 Dec 13;9:359
pubmed: 21144034
Biometrics. 1977 Mar;33(1):159-74
pubmed: 843571
Nature. 2000 Mar 16;404(6775):307-10
pubmed: 10749217
Mol Biochem Parasitol. 2003 Aug 31;130(2):91-9
pubmed: 12946845
Blood. 1996 Dec 15;88(12):4694-700
pubmed: 8977263
J Biomed Opt. 2012 Jan;17(1):017005
pubmed: 22352671
J Infect Dis. 2007 Feb 15;195(4):589-96
pubmed: 17230420
Malar J. 2008 Apr 25;7:66
pubmed: 18439240
Nat Med. 2015 Dec;21(12):1387
pubmed: 26646490
Trans R Soc Trop Med Hyg. 1993 Jul-Aug;87(4):436-43
pubmed: 8249075
J Biol Chem. 1997 Jan 10;272(2):713-6
pubmed: 8995354
Parasitology. 1996 Mar;112 ( Pt 3):285-94
pubmed: 8728992
Am J Trop Med Hyg. 2011 Nov;85(5):815-7
pubmed: 22049032
J Infect Dis. 2019 Apr 16;219(9):1490-1498
pubmed: 30476111
Int J Parasitol. 1994 Apr;24(2):165-6
pubmed: 8026892
Malar J. 2010 Jul 19;9:207
pubmed: 20642834
Am J Trop Med Hyg. 2012 Aug;87(2):223-230
pubmed: 22855751
PLoS Negl Trop Dis. 2015 May 21;9(5):e0003758
pubmed: 25996619
Acta Trop. 2016 Aug;160:1-8
pubmed: 27056132
Lancet Infect Dis. 2018 Oct;18(10):1108-1116
pubmed: 30170986
Lancet. 1981 Jul 11;2(8237):70-1
pubmed: 6113443
PLoS Med. 2015 Oct 27;12(10):e1001891
pubmed: 26505753
Parasitology. 2001 Aug;123(Pt 2):125-31
pubmed: 11510677
Malar J. 2016 Feb 16;15:88
pubmed: 26879936
Sci Rep. 2020 Aug 20;10(1):14025
pubmed: 32820190
Biochim Biophys Acta. 2014 Jun;1840(6):2032-41
pubmed: 24556123
Am J Clin Pathol. 1995 Jan;103(1):57-64
pubmed: 7817946
PLoS One. 2015 Nov 10;10(11):e0142842
pubmed: 26555068
Science. 1996 Jan 12;271(5246):219-22
pubmed: 8539625
Front Immunol. 2017 Sep 20;8:1148
pubmed: 28979260
Trends Parasitol. 2003 Jun;19(6):253-9
pubmed: 12798082
Nature. 2002 Feb 7;415(6872):680-5
pubmed: 11832956
Biochim Biophys Acta. 2009 Feb;1792(2):93-9
pubmed: 19056489
PLoS One. 2014 May 13;9(5):e96981
pubmed: 24824542
Trends Parasitol. 2002 Sep;18(9):395-8
pubmed: 12377256
Sci Rep. 2013;3:1431
pubmed: 23478535
Clin Microbiol Infect. 2011 Nov;17(11):1624-31
pubmed: 21910780
J Clin Microbiol. 2017 Jul;55(7):2009-2017
pubmed: 28404673
J Immunol. 2004 Sep 15;173(6):4066-74
pubmed: 15356156
Front Public Health. 2017 Nov 20;5:307
pubmed: 29209603
Biomolecules. 2019 Oct 07;9(10):
pubmed: 31591333
Malar J. 2010 Dec 14;9:361
pubmed: 21156052
Malar J. 2014 Apr 16;13:145
pubmed: 24739250
Antimicrob Agents Chemother. 2015 Aug;59(8):4489-96
pubmed: 25987625
J Clin Microbiol. 2000 Nov;38(11):4072-5
pubmed: 11060070
Sci Rep. 2016 Mar 17;6:23218
pubmed: 26983695
Am J Trop Med Hyg. 2006 Apr;74(4):568-72
pubmed: 16606985
Ann Trop Med Parasitol. 1997 Jul;91(5):501-16
pubmed: 9329987
Nat Med. 2014 Sep;20(9):1069-73
pubmed: 25173428
Parassitologia. 2008 Jun;50(1-2):143-5
pubmed: 18693582
Proc Natl Acad Sci U S A. 1936 Apr;22(4):210-6
pubmed: 16577697
Virchows Arch A Pathol Pathol Anat. 1969;348(3):220-9
pubmed: 4901538
PLoS One. 2013 Sep 27;8(9):e76316
pubmed: 24312682
Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):325-9
pubmed: 1988933
Caspian J Intern Med. 2013 Spring;4(2):627-35
pubmed: 24009950
Clin Oncol (R Coll Radiol). 2008 Feb;20(1):92-3
pubmed: 17931844
Trends Parasitol. 2013 Oct;29(10):469-76
pubmed: 23937890
J Infect Dis. 2017 Dec 12;216(11):1434-1443
pubmed: 29029179
Am J Trop Med Hyg. 2011 Jan;84(1):158-60
pubmed: 21212220
Biophys J. 2008 Jul;95(2):994-1000
pubmed: 18390603
Clin Microbiol Rev. 2002 Jan;15(1):66-78
pubmed: 11781267
Malar Res Treat. 2012;2012:373086
pubmed: 22567535