DNA methylation status correlates with adult β-cell regeneration capacity.
Journal
NPJ Regenerative medicine
ISSN: 2057-3995
Titre abrégé: NPJ Regen Med
Pays: United States
ID NLM: 101699846
Informations de publication
Date de publication:
12 Feb 2021
12 Feb 2021
Historique:
received:
15
11
2020
accepted:
14
01
2021
entrez:
13
2
2021
pubmed:
14
2
2021
medline:
14
2
2021
Statut:
epublish
Résumé
The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood, a well described pathophysiological phenomenon of major significance in explaining β-cell deficiency in diabetes in the adult pancreas.
Identifiants
pubmed: 33580013
doi: 10.1038/s41536-021-00119-1
pii: 10.1038/s41536-021-00119-1
pmc: PMC7881134
doi:
Types de publication
Journal Article
Langues
eng
Pagination
7Références
Nat Genet. 1998 Jun;19(2):187-91
pubmed: 9620779
Dev Dyn. 2011 Mar;240(3):589-604
pubmed: 21287656
Development. 2002 May;129(10):2447-57
pubmed: 11973276
Cell. 2008 Jan 25;132(2):197-207
pubmed: 18243096
Mol Cell Biol. 2002 Mar;22(6):1844-57
pubmed: 11865062
Dev Cell. 2013 Jul 15;26(1):86-100
pubmed: 23810513
Proc Natl Acad Sci U S A. 2013 May 28;110(22):8948-53
pubmed: 23696663
Genes Dev. 2016 Apr 1;30(7):733-50
pubmed: 27036965
PLoS Genet. 2013 Oct;9(10):e1003934
pubmed: 24204325
Cell. 2009 Aug 7;138(3):449-62
pubmed: 19665969
Development. 2005 Jul;132(13):2969-80
pubmed: 15930104
Development. 2000 Aug;127(16):3533-42
pubmed: 10903178
Genome Res. 2011 Oct;21(10):1601-15
pubmed: 21890681
Cell Stem Cell. 2010 Jul 2;7(1):51-63
pubmed: 20621050