Intermittent theta burst stimulation for negative symptoms of schizophrenia-A double-blind, sham-controlled pilot study.
Journal
NPJ schizophrenia
ISSN: 2334-265X
Titre abrégé: NPJ Schizophr
Pays: United States
ID NLM: 101657919
Informations de publication
Date de publication:
12 Feb 2021
12 Feb 2021
Historique:
received:
19
08
2020
accepted:
22
12
2020
entrez:
13
2
2021
pubmed:
14
2
2021
medline:
14
2
2021
Statut:
epublish
Résumé
Optimal noninvasive brain stimulation parameters for the treatment of negative symptoms of schizophrenia remain unclear. Here, we aimed to investigate the clinical and biological effects of intermittent theta burst transcranial magnetic stimulation (iTBS) in patients with treatment-resistant negative symptoms of schizophrenia (NCT00875498). In a randomized sham-controlled 2-arm study, 22 patients with schizophrenia and treatment-resistant negative symptoms received 20 sessions of either active (n = 12) or sham (n = 10) iTBS. Sessions were delivered twice a day on 10 consecutive working days. Negative symptom severity was assessed 5 times using the Scale for the Assessment of Negative Symptoms (SANS): before iTBS, after iTBS, and 1, 3, and 6 months after iTBS. As a secondary objective, we explored the acute effects of iTBS on functional connectivity of the left dorsolateral prefrontal cortex (DLPFC) using seed-based resting-state functional connectivity MRI (rsFC fMRI) images acquired before and after iTBS. Active iTBS over the left DLPFC significantly decreased negative symptoms severity compared to sham iTBS (F
Identifiants
pubmed: 33580032
doi: 10.1038/s41537-021-00138-3
pii: 10.1038/s41537-021-00138-3
pmc: PMC7880987
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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