Targeted deletion of Ruvbl1 results in severe defects of epidermal development and perinatal mortality.


Journal

Molecular and cellular pediatrics
ISSN: 2194-7791
Titre abrégé: Mol Cell Pediatr
Pays: Germany
ID NLM: 101660689

Informations de publication

Date de publication:
12 Feb 2021
Historique:
received: 10 11 2020
accepted: 26 01 2021
entrez: 13 2 2021
pubmed: 14 2 2021
medline: 14 2 2021
Statut: epublish

Résumé

Epidermal development is a complex process of regulated cellular proliferation, differentiation, and tightly controlled cell death involving multiple cellular signaling networks. Here, we report a first description linking the AAA+ (ATPases associated with various cellular activities) superfamily protein Ruvbl1 to mammalian epidermal development. Keratinocyte-specific Ruvbl1 knockout mice (Ruvbl1

Identifiants

pubmed: 33580312
doi: 10.1186/s40348-021-00111-1
pii: 10.1186/s40348-021-00111-1
pmc: PMC7881068
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : LI 2397 5/1
Organisme : Bundesministerium für Bildung und Forschung
ID : 01GM1903B

Références

Biochim Biophys Acta. 2011 Apr;1815(2):147-57
pubmed: 21111787
Exp Mol Med. 2018 Jun 28;50(6):1-17
pubmed: 29959317
J Dev Biol. 2017 Nov 20;5(4):
pubmed: 29615568
Mol Cell. 2009 Jun 12;34(5):521-33
pubmed: 19524533
Horm Res. 2000;54(5-6):296-300
pubmed: 11595821
Trends Cell Biol. 2007 Apr;17(4):187-92
pubmed: 17320397
Organogenesis. 2018 Jan 2;14(1):46-63
pubmed: 29420124
Mol Cell. 2006 Dec 28;24(6):841-51
pubmed: 17189187
Adv Exp Med Biol. 2018;1106:73-83
pubmed: 30484153
Eur J Dermatol. 2020 Feb 1;30(1):52-53
pubmed: 32031537
Sci Signal. 2013 Mar 12;6(266):mr1
pubmed: 23482663
Arthritis Care Res (Hoboken). 2014 Apr;66(4):575-84
pubmed: 24023044
Nat Rev Mol Cell Biol. 2015 Jul;16(7):393-405
pubmed: 26122615
Biomol Concepts. 2014 Dec;5(6):513-20
pubmed: 25429602
Int J Mol Sci. 2013 May 24;14(6):10869-95
pubmed: 23708093
Philos Trans R Soc Lond B Biol Sci. 2013 Mar 25;368(1617):20110399
pubmed: 23530256
Mol Cell Biol. 2008 Apr;28(8):2690-700
pubmed: 18285460
Annu Rev Cell Dev Biol. 2007;23:93-113
pubmed: 17489688
RNA Biol. 2012 Feb;9(2):148-54
pubmed: 22418846
Haematologica. 2012 Sep;97(9):1291-4
pubmed: 22371176

Auteurs

Claudia Dafinger (C)

Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Department II of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Thomas Benzing (T)

Department II of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Systems Biology of Ageing Cologne, University of Cologne, Cologne, Germany.
Center for Molecular Medicine, University of Cologne, Cologne, Germany.

Jörg Dötsch (J)

Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.

Bernhard Schermer (B)

Department II of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Systems Biology of Ageing Cologne, University of Cologne, Cologne, Germany.
Center for Molecular Medicine, University of Cologne, Cologne, Germany.

Max C Liebau (MC)

Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany. max.liebau@uk-koeln.de.
Department II of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. max.liebau@uk-koeln.de.
Center for Molecular Medicine, University of Cologne, Cologne, Germany. max.liebau@uk-koeln.de.

Classifications MeSH