Outpatient metformin use is associated with reduced severity of COVID-19 disease in adults with overweight or obesity.
Anti-Inflammatory Agents
/ therapeutic use
Antiviral Agents
/ therapeutic use
Body Mass Index
Glycated Hemoglobin
/ analysis
Hospitalization
/ statistics & numerical data
Humans
Interleukin-6
/ blood
Metformin
/ therapeutic use
Obesity
Retrospective Studies
SARS-CoV-2
/ drug effects
Treatment Outcome
COVID-19 Drug Treatment
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
08
02
2021
received:
22
12
2020
accepted:
10
02
2021
pubmed:
14
2
2021
medline:
9
6
2021
entrez:
13
2
2021
Statut:
ppublish
Résumé
Observational studies suggest outpatient metformin use is associated with reduced mortality from coronavirus disease-2019 (COVID-19). Metformin is known to decrease interleukin-6 and tumor-necrosis factor-α, which appear to contribute to morbidity in COVID-19. We sought to understand whether outpatient metformin use was associated with reduced odds of severe COVID-19 disease in a large US healthcare data set. Retrospective cohort analysis of electronic health record (EHR) data that was pooled across multiple EHR systems from 12 hospitals and 60 primary care clinics in the Midwest between March 4, 2020 and December 4, 2020. Inclusion criteria: data for body mass index (BMI) > 25 kg/m
Identifiants
pubmed: 33580540
doi: 10.1002/jmv.26873
pmc: PMC8013587
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Antiviral Agents
0
Glycated Hemoglobin A
0
IL6 protein, human
0
Interleukin-6
0
hemoglobin A1c protein, human
0
Metformin
9100L32L2N
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4273-4279Subventions
Organisme : NCATS NIH HHS
ID : UL1TR002489
Pays : United States
Organisme : Agency for Healthcare Research and Quality
ID : K12HS026379
Organisme : NCATS NIH HHS
ID : UL1 TR002494
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1TR002494
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL133604
Pays : United States
Organisme : UMN Rapid Response Covid Grant
ID : UM 2020-2231
Organisme : NCATS NIH HHS
ID : KL2TR002492
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32HL07741
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK048520
Pays : United States
Organisme : Minnesota Learning Health System Mentored Training Program (MH-LHS), M Health Fairview Institutional Funds
Organisme : NHLBI NIH HHS
ID : 1K23HL133604
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002489
Pays : United States
Informations de copyright
© 2021 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC.
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