The reversible reproductive toxicity of 5-fluorouracil in mice.
5-Fluorouracil
Embryonic development
Female fertility
Oocyte maturation
Ovary
Ovulation failure
Reproductive toxicology
Reversible
Journal
Reproductive toxicology (Elmsford, N.Y.)
ISSN: 1873-1708
Titre abrégé: Reprod Toxicol
Pays: United States
ID NLM: 8803591
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
14
08
2020
revised:
15
01
2021
accepted:
03
02
2021
pubmed:
14
2
2021
medline:
16
11
2021
entrez:
13
2
2021
Statut:
ppublish
Résumé
5-Fluorouracil (5-FU) is a "cytotoxic" drug used for cancer chemotherapy, which inhibits cells division via affecting DNA synthesis. Although being widely used for cancer treatment, 5-FU has non-negligible side effects. In the present study, the effects of 5-FU on oocyte and early embryonic development were investigated. Multiple intraperitoneal administration of 5-FU (50 mg/kg/day) in female mice resulted in small ovarian size and reduced number of corpus luteum in the ovary, and lead to ovulation failure. However, these defects could be recovered after one week. In vitro experiments further indicated that exposure to 5-FU inhibited oocytes maturation and reduced developmental potential of pre-implantation embryos. Our data suggested that 5-FU has negative impact on ovarian function, oocyte and early embryonic development, but the adverse effect could be reversed after withdrawal of 5-FU administration.
Identifiants
pubmed: 33581264
pii: S0890-6238(21)00032-0
doi: 10.1016/j.reprotox.2021.02.002
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Fluorouracil
U3P01618RT
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-8Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.