Higher-order sensorimotor circuit of the brain's global network supports human consciousness.
Adult
Anesthesia
/ methods
Anesthetics, Intravenous
/ administration & dosage
Consciousness
/ drug effects
Electroencephalography
/ methods
Female
Humans
Magnetic Resonance Imaging
/ methods
Male
Nerve Net
/ diagnostic imaging
Sensorimotor Cortex
/ diagnostic imaging
Sleep, REM
/ drug effects
Wakefulness
/ drug effects
Young Adult
Anesthesia
Degree centrality
Disorders of consciousness
Higher-order sensorimotor circuit
Inferior parietal lobule
Rapid eye movement sleep
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
01 05 2021
01 05 2021
Historique:
received:
16
10
2020
revised:
29
12
2020
accepted:
08
02
2021
pubmed:
15
2
2021
medline:
16
10
2021
entrez:
14
2
2021
Statut:
ppublish
Résumé
Consciousness is a mental characteristic of the human mind, whose exact neural features remain unclear. We aimed to identify the critical nodes within the brain's global functional network that support consciousness. To that end, we collected a large fMRI resting state dataset with subjects in at least one of the following three consciousness states: preserved (including the healthy awake state, and patients with a brain injury history (BI) that is fully conscious), reduced (including the N1-sleep state, and minimally conscious state), and lost (including the N3-sleep state, anesthesia, and unresponsive wakefulness state). We also included a unique dataset of subjects in rapid eye movement sleep state (REM-sleep) to test for the presence of consciousness with minimum movements and sensory input. To identify critical nodes, i.e., hubs, within the brain's global functional network, we used a graph-theoretical measure of degree centrality conjoined with ROI-based functional connectivity. Using these methods, we identified various higher-order sensory and motor regions including the supplementary motor area, bilateral supramarginal gyrus (part of inferior parietal lobule), supragenual/dorsal anterior cingulate cortex, and left middle temporal gyrus, that could be important hubs whose degree centrality was significantly reduced when consciousness was reduced or absent. Additionally, we identified a sensorimotor circuit, in which the functional connectivity among these regions was significantly correlated with levels of consciousness across the different groups, and remained present in the REM-sleep group. Taken together, we demonstrated that regions forming a higher-order sensorimotor integration circuit are involved in supporting consciousness within the brain's global functional network. That offers novel and more mechanism-guided treatment targets for disorders of consciousness.
Identifiants
pubmed: 33582277
pii: S1053-8119(21)00127-0
doi: 10.1016/j.neuroimage.2021.117850
pmc: PMC9583596
mid: NIHMS1840961
pii:
doi:
Substances chimiques
Anesthetics, Intravenous
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
117850Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM103894
Pays : United States
Organisme : CIHR
Pays : Canada
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None declared.
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