Longitudinal analysis of antibody response following SARS-CoV-2 infection in pregnancy: From the first trimester to delivery.

Adult Antibodies, Neutralizing / blood Antibodies, Viral / blood COVID-19 / blood Female Humans Immunoglobulin G / blood Longitudinal Studies Pregnancy Pregnancy Complications, Infectious / blood SARS-CoV-2 / immunology
Antibodies COVID-19 immunology COVID-19 vaccines Pregnancy SARS-CoV-2

Journal

Journal of reproductive immunology
ISSN: 1872-7603
Titre abrégé: J Reprod Immunol
Pays: Ireland
ID NLM: 8001906

Informations de publication

Date de publication:
04 2021
Historique:
received: 08 01 2021
accepted: 28 01 2021
pubmed: 15 2 2021
medline: 9 3 2021
entrez: 14 2 2021
Statut: ppublish

Résumé

We report herein the longest-lasting study of SARS-CoV-2 antibody profile in pregnancy, from first trimester-infection to delivery. Seventeen out of 164 pregnant women tested positive for COVID-19. Throughout pregnancy, the neutralizing antibody titer remained stable, whilst a significant decline in the non-neutralizing antibodies was observed after 16 weeks of gestation. All the newborns of women who developed IgG antibodies showed the presence of the same antibodies in arterial cord blood. Knowledge on the longevity and type of SARS-CoV-2 antibody response may help to guide vaccination strategies in pregnancy.

Identifiants

DOI: 10.1016/j.jri.2021.103285 PMID: 33582489 PMC: PMC7973007
pubmed: 33582489
pii: S0165-0378(21)00015-2
doi: 10.1016/j.jri.2021.103285
pmc: PMC7973007
pii:
doi:

Substances chimiques

Antibodies, Neutralizing 0
Antibodies, Viral 0
Immunoglobulin G 0

Types de publication

Clinical Trial Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

103285

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Références

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pubmed: 31088698
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pubmed: 33351086
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pubmed: 32979941
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pubmed: 32418711

Auteurs

Stefano Cosma (S)

Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, Turin, Italy.

Andrea Roberto Carosso (AR)

Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, Turin, Italy. Electronic address: andrea88.carosso@gmail.com.

Silvia Corcione (S)

Infectious Diseases, Department of Medical Sciences, University of Turin, Turin, Italy; Tufts University School of Medicine, Boston, MA, USA.

Jessica Cusato (J)

Laboratory of Clinical Pharmacology and Pharmacogenetics, Amedeo di Savoia Hospital, Department of Medical Sciences, University of Turin, Turin, Italy.

Fulvio Borella (F)

Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, Turin, Italy.

Miriam Antonucci (M)

Laboratory of Clinical Pharmacology and Pharmacogenetics, Amedeo di Savoia Hospital, Department of Medical Sciences, University of Turin, Turin, Italy.

Luca Marozio (L)

Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, Turin, Italy.

Alberto Revelli (A)

Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, Turin, Italy.

Mario Preti (M)

Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, Turin, Italy.

Valeria Ghisetti (V)

Laboratory of Microbiology and Virology, Amedeo di Savoia Hospital, ASL 'Città di Torino', Turin, Italy.

Giovanni Di Perri (G)

Unit of Infectious Diseases, Amedeo di Savoia Hospital, Department of Medical Sciences, University of Turin, Turin, Italy.

Chiara Benedetto (C)

Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, Turin, Italy.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Longitudinal analysis of antibody response...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › Longitudinal analysis of antibody response...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Longitudinal analysis of antibody response...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Longitudinal analysis of antibody response...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Longitudinal analysis of antibody response...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline G › Longitudinal analysis of antibody response...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › Longitudinal analysis of antibody response...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Longitudinal analysis of antibody response...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Complications infectieuses de la grossesse › Longitudinal analysis of antibody response...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Longitudinal analysis of antibody response...