Metal Nanoparticles/MoS
Au−Ag core−shell nanostructures
immunosensor
molybdenum disulfide
surface-enhanced Raman scattering (SERS)
α-fetoprotein
Journal
ACS applied materials & interfaces
ISSN: 1944-8252
Titre abrégé: ACS Appl Mater Interfaces
Pays: United States
ID NLM: 101504991
Informations de publication
Date de publication:
24 Feb 2021
24 Feb 2021
Historique:
pubmed:
16
2
2021
medline:
6
3
2021
entrez:
15
2
2021
Statut:
ppublish
Résumé
The detection of cancer biomarkers at an early stage of tumor development is vital for effective diagnosis and treatment of cancer. Current diagnostic tools can often detect cancer only when the biomarker levels are already too high, so that the tumors have spread and treatments are less effective. It is urgent therefore to develop highly sensitive assays for the detection of such biomarkers at the lowest possible concentration. In this context, we developed a sandwich immunoassay based on surface-enhanced Raman scattering (SERS) for the ultrasensitive detection of α-fetoprotein (AFP), which is typically present in human serum as a biomarker indicative of early stages of hepatocellular carcinoma. In the immunoassay design, molybdenum disulfide (MoS
Identifiants
pubmed: 33583183
doi: 10.1021/acsami.0c22203
pmc: PMC7908013
doi:
Substances chimiques
AFP protein, human
0
Disulfides
0
alpha-Fetoproteins
0
Silver
3M4G523W1G
Gold
7440-57-5
Molybdenum
81AH48963U
molybdenum disulfide
ZC8B4P503V
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8823-8831Références
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