Muscle activity and acute stress in fibromyalgia.
Journal
BMC musculoskeletal disorders
ISSN: 1471-2474
Titre abrégé: BMC Musculoskelet Disord
Pays: England
ID NLM: 100968565
Informations de publication
Date de publication:
14 Feb 2021
14 Feb 2021
Historique:
received:
23
04
2020
accepted:
25
01
2021
entrez:
15
2
2021
pubmed:
16
2
2021
medline:
15
5
2021
Statut:
epublish
Résumé
Fibromyalgia (FM) patients are likely to differ from healthy controls in muscle activity and in reactivity to experimental stress. We compared psychophysiological reactivity to cognitive stress between 51 female FM patients aged 18 to 65 years and 31 age- and sex-matched healthy controls. They underwent a 20-minute protocol consisting of three phases of relaxation and two phases of cognitive stress. We recorded surface electromyography normalized to maximum voluntary muscle contraction (%EMG), the percentage of time with no muscle activity (EMG rest time), and subjective pain and stress intensities. We compared group reactivity using linear modelling and adjusted for psychological and life-style factors. The FM patients had a significantly higher mean %EMG (2.2 % vs. 1.0 %, p < 0.001), pain intensity (3.6 vs. 0.2, p < 0.001), and perceived stress (3.5 vs. 1.4, p < 0.001) and lower mean EMG rest time (26.7 % vs. 47.2 %, p < 0.001). In the FM patients, compared with controls, the pain intensity increased more during the second stress phase (0.71, p = 0.028), and the %EMG decreased more during the final relaxation phase (-0.29, p = 0.036). Within the FM patients, higher BMI predicted higher %EMG but lower stress. Leisure time physical activity predicted lower %EMG and stress and higher EMG rest time. Higher perceived stress predicted lower EMG rest time, and higher trait anxiety predicted higher pain and stress overall. Our results suggest that repeated cognitive stress increases pain intensity in FM patients. FM patients also had higher resting muscle activity, but their muscle activity did not increase with pain. Management of stress and anxiety might help control FM flare-ups. Retrospectively registered on ClinicalTrials.gov ( NCT03300635 ).
Sections du résumé
BACKGROUND
BACKGROUND
Fibromyalgia (FM) patients are likely to differ from healthy controls in muscle activity and in reactivity to experimental stress.
METHODS
METHODS
We compared psychophysiological reactivity to cognitive stress between 51 female FM patients aged 18 to 65 years and 31 age- and sex-matched healthy controls. They underwent a 20-minute protocol consisting of three phases of relaxation and two phases of cognitive stress. We recorded surface electromyography normalized to maximum voluntary muscle contraction (%EMG), the percentage of time with no muscle activity (EMG rest time), and subjective pain and stress intensities. We compared group reactivity using linear modelling and adjusted for psychological and life-style factors.
RESULTS
RESULTS
The FM patients had a significantly higher mean %EMG (2.2 % vs. 1.0 %, p < 0.001), pain intensity (3.6 vs. 0.2, p < 0.001), and perceived stress (3.5 vs. 1.4, p < 0.001) and lower mean EMG rest time (26.7 % vs. 47.2 %, p < 0.001). In the FM patients, compared with controls, the pain intensity increased more during the second stress phase (0.71, p = 0.028), and the %EMG decreased more during the final relaxation phase (-0.29, p = 0.036). Within the FM patients, higher BMI predicted higher %EMG but lower stress. Leisure time physical activity predicted lower %EMG and stress and higher EMG rest time. Higher perceived stress predicted lower EMG rest time, and higher trait anxiety predicted higher pain and stress overall.
CONCLUSIONS
CONCLUSIONS
Our results suggest that repeated cognitive stress increases pain intensity in FM patients. FM patients also had higher resting muscle activity, but their muscle activity did not increase with pain. Management of stress and anxiety might help control FM flare-ups.
TRIAL REGISTRATION
BACKGROUND
Retrospectively registered on ClinicalTrials.gov ( NCT03300635 ).
Identifiants
pubmed: 33583408
doi: 10.1186/s12891-021-04013-1
pii: 10.1186/s12891-021-04013-1
pmc: PMC7883576
doi:
Banques de données
ClinicalTrials.gov
['NCT03300635']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
183Subventions
Organisme : Tekes
ID : TYH2017215
Références
PLoS One. 2013 Aug 07;8(8):e69460
pubmed: 23950894
BMC Rheumatol. 2019 Jun 24;3:5
pubmed: 31286111
Scand J Rheumatol. 2001;30(2):92-8
pubmed: 11324796
J Electromyogr Kinesiol. 2017 Dec;37:1-8
pubmed: 28841523
BMC Musculoskelet Disord. 2007 Mar 09;8:27
pubmed: 17349056
Pain. 2016 Jul;157(7):1382-1386
pubmed: 26835783
Neuroscience. 2016 Dec 3;338:114-129
pubmed: 27291641
Clin Exp Rheumatol. 2005 Sep-Oct;23(5 Suppl 39):S154-62
pubmed: 16273800
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Dec 20;87(Pt B):168-182
pubmed: 29408484
J Psychosom Res. 2006 Nov;61(5):671-9
pubmed: 17084146
Pain. 2016 Oct;157(10):2269-2276
pubmed: 27355183
Arthritis Res Ther. 2011 Apr 28;13(2):211
pubmed: 21542893
PLoS One. 2016 Oct 3;11(10):e0162010
pubmed: 27695113
BMC Musculoskelet Disord. 2007 Aug 14;8:81
pubmed: 17697337
J Pain. 2010 Jul;11(7):644-51
pubmed: 19914876
Asian Nurs Res (Korean Soc Nurs Sci). 2012 Dec;6(4):121-7
pubmed: 25031113
J Health Soc Behav. 1983 Dec;24(4):385-96
pubmed: 6668417
Scand J Pain. 2017 Dec 29;3(1):15-20
pubmed: 29913759
Arthritis Rheum. 1990 Feb;33(2):160-72
pubmed: 2306288
J Electromyogr Kinesiol. 2019 Dec;49:102363
pubmed: 31665683
Curr Rheumatol Rep. 2012 Dec;14(6):557-67
pubmed: 22936576
BMC Musculoskelet Disord. 2013 Mar 18;14:97
pubmed: 23506457