Can what have we learnt about BCG vaccination in the last 20 years help us to design a better tuberculosis vaccine?
BCG
BCG vaccination
TB vaccines
Trained immunity
Tuberculosis
Journal
Vaccine
ISSN: 1873-2518
Titre abrégé: Vaccine
Pays: Netherlands
ID NLM: 8406899
Informations de publication
Date de publication:
08 03 2022
08 03 2022
Historique:
received:
07
09
2020
revised:
20
01
2021
accepted:
27
01
2021
pubmed:
16
2
2021
medline:
11
3
2022
entrez:
15
2
2021
Statut:
ppublish
Résumé
The BCG vaccine will, in 2021, have been in use for 100 years. Much remains to be understood, including the reasons for its variable efficacy against pulmonary tuberculosis in adults. This review will discuss what has been learnt about the BCG vaccine in the last two decades, and whether this new information can be exploited to improve its efficacy, by enhancing its ability to induce either antigen-specific and/or non-specific effects. Many factors affect both the immunogenicity of BCG and its protective efficacy, highlighting the challenges of working with a live vaccine in man, but new insights may enable us to exploit better what BCG can do.
Identifiants
pubmed: 33583672
pii: S0264-410X(21)00109-2
doi: 10.1016/j.vaccine.2021.01.068
pmc: PMC8899334
pii:
doi:
Substances chimiques
BCG Vaccine
0
Tuberculosis Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1525-1533Subventions
Organisme : Medical Research Council
ID : MR/R005850/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N013638/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom
Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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