Age-related Epstein-Barr Virus-associated Lymphoproliferative Disorder Masquerading as Systemic Lupus Erythematosus.
Epstein-Barr virus
lymphoproliferative disorder
systemic lupus erythematosus
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
01 Aug 2021
01 Aug 2021
Historique:
pubmed:
16
2
2021
medline:
4
8
2021
entrez:
15
2
2021
Statut:
ppublish
Résumé
Age-related Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative disorder (LPD) occurs in elderly patients without immunodeficiency. An 81-year-old woman without any known immunodeficiency was examined for fever, rash, arthritis, thrombocytopenia, pleural and pericardial effusions, lymphadenopathy, and positive autoantibodies, which satisfied the classification criteria for systemic lupus erythematosus (SLE). However, a lymph node biopsy revealed EBV-LPD, and she was diagnosed with age-related EBV-LPD. In young individuals, EBV infection is a major differential diagnosis of SLE, but to our knowledge, this is the first reported case of age-related EBV-LPD mimicking SLE. We should therefore consider EBV-related disorders in the differential diagnosis of SLE even in elderly individuals.
Identifiants
pubmed: 33583902
doi: 10.2169/internalmedicine.6702-20
pmc: PMC8381174
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2495-2497Références
Clin Cancer Res. 2007 Sep 1;13(17):5124-32
pubmed: 17785567
Clin Dev Immunol. 2012;2012:370516
pubmed: 22811739
Joint Bone Spine. 2019 Mar;86(2):165-171
pubmed: 30837156
Scand J Clin Lab Invest. 2019 Feb - Apr;79(1-2):7-16
pubmed: 30727744
Ann Rheum Dis. 2018 Sep;77(9):1249-1250
pubmed: 29858172
Blood. 2011 May 5;117(18):4726-35
pubmed: 21385849
Pathol Res Pract. 2007;203(8):587-91
pubmed: 17662540
Arthritis Rheum. 2012 Aug;64(8):2677-86
pubmed: 22553077
Nat Rev Dis Primers. 2016 Jun 16;2:16039
pubmed: 27306639
Pathol Int. 2009 Dec;59(12):835-43
pubmed: 20021607
Pathol Int. 2020 Aug;70(8):481-492
pubmed: 32367595