Correlation Between Height and Impacted Third Molars and Genetics Role in Third Molar Impaction.
Genetics
Height
Impactions
Third molars
WNT9B
Journal
Journal of maxillofacial and oral surgery
ISSN: 0972-8279
Titre abrégé: J Maxillofac Oral Surg
Pays: India
ID NLM: 101538309
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
06
05
2019
accepted:
23
01
2020
entrez:
15
2
2021
pubmed:
16
2
2021
medline:
16
2
2021
Statut:
ppublish
Résumé
This study sought to evaluate the relationship between height of an individual and the presence of impaction of maxillary and mandibular third molars, and to determine the role of genetics in third molar impaction. This was a case-control study, with cases consisted of 200 subjects with third molar impactions; and 200 controls without third molar impactions. Height of subjects was measured, and saliva samples were collected from all the subjects. DNA was extracted from saliva samples. To investigate the role of selected genes in the etiology of third molar impactions, Taqman Genotyping using SNPs identified for jaw growth, height and tooth agenesis was employed. Five candidate genes were investigated using 11 markers (SNPs). The mean height of cases was significantly lower than that of the control subjects ( Subjects with lower third molar impactions were significantly shorter than those who have fully erupted third molars. We observed that individuals with third molar impaction tend to have T allele at the locus, suggesting that the T allele at the locus may increase the risk for having an impacted third molar. The rs6504591 G/T variation on human chromosome 17 (WNT9B gene) appears to increase risk by twofolds for impaction albeit with inability to detect significance due to small sample size.
Identifiants
pubmed: 33584057
doi: 10.1007/s12663-020-01336-9
pii: 1336
pmc: PMC7855106
doi:
Types de publication
Journal Article
Langues
eng
Pagination
149-153Subventions
Organisme : NIDCR NIH HHS
ID : R00 DE022378
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE028300
Pays : United States
Informations de copyright
© The Association of Oral and Maxillofacial Surgeons of India 2020.
Déclaration de conflit d'intérêts
Conflict of interestAll authors declare that they have no conflict of interest.
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