Functional Network Profiles in ARSACS Disclosed by Aptamer-Based Proteomic Technology.
ARSACS
SomaLogic technology
engulfment of cells
neuroinflammation
proteomic analysis
sacsin
synaptogenesis
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
09
2020
accepted:
16
12
2020
entrez:
15
2
2021
pubmed:
16
2
2021
medline:
16
2
2021
Statut:
epublish
Résumé
Although the genetic basis of autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) has been uncovered, our poor understanding of disease mechanisms requires new light on functional pathways and modifying factors to improve early diagnostic strategies and offer alternative treatment options in a rare condition with no cure. Investigation of the pathologic state combining disease models and quantitative omic approach might improve biomarkers discovery with possible implications in patients' diagnoses. In this study, we analyzed proteomics data obtained using the SomaLogic technology, comparing cell lysates from ARSACS patients and from a
Identifiants
pubmed: 33584503
doi: 10.3389/fneur.2020.603774
pmc: PMC7873355
doi:
Types de publication
Journal Article
Langues
eng
Pagination
603774Informations de copyright
Copyright © 2021 Morani, Doccini, Chiorino, Fattori, Galatolo, Sciarrillo, Gemignani, Züchner, Bertini and Santorelli.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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