Levothyroxine Therapy in Gastric Malabsorptive Disorders.
Helicobacter pylori
gastritis
hypothyroidism
levothyroxine
liquid levothyroxine
malabsorption
proton pump inhibitors
softgel levothyroxine
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
10
2020
accepted:
11
12
2020
entrez:
15
2
2021
pubmed:
16
2
2021
medline:
27
5
2021
Statut:
epublish
Résumé
Oral levothyroxine sodium is absorbed in the small intestine, mainly in the jejunum and the ileum being lower the absorption rate at duodenal level. The time interval between the ingestion of oral thyroxine and its appearance in the plasma renders unlike a gastric absorption of the hormone. However, several evidence confirm the key role of the stomach as a prerequisite for an efficient absorption of oral levothyroxine. In the stomach, in fact, occur key steps leading to the dissolution of thyroxine from the solid form, the process bringing the active ingredient from the pharmaceutical preparation to the aqueous solution. In particular, gastric juice pH, volume, viscosity, as well as gastric emptying time seem to be the most important limiting factors. These hypotheses are confirmed by the detection of an increased need for levothyroxine in patients with
Identifiants
pubmed: 33584549
doi: 10.3389/fendo.2020.621616
pmc: PMC7876372
doi:
Substances chimiques
Thyroxine
Q51BO43MG4
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
621616Informations de copyright
Copyright © 2021 Virili, Brusca, Capriello and Centanni.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Thyroid. 2018 Apr;28(4):454-457
pubmed: 29589994
J Pharm Sci. 2004 Dec;93(12):3066-75
pubmed: 15515180
Endocrine. 2019 Oct;66(1):10-17
pubmed: 31321670
Endocrine. 2019 Oct;66(1):87-94
pubmed: 31617168
Endocr Rev. 2008 Feb;29(1):76-131
pubmed: 17991805
F1000Res. 2017 Sep 28;6:1776
pubmed: 29043075
Scand J Gastroenterol. 2015 Jun;50(6):657-67
pubmed: 25901896
Aliment Pharmacol Ther. 1996 Feb;10(1):105-9
pubmed: 8871450
Best Pract Res Clin Endocrinol Metab. 2005 Mar;19(1):17-32
pubmed: 15826920
Nat Rev Dis Primers. 2018 Nov 1;4(1):41
pubmed: 30385743
J Pharm Sci. 2016 Sep;105(9):2545-2555
pubmed: 27506604
Clin Pharmacokinet. 1978 Sep-Oct;3(5):337-51
pubmed: 81118
Endocrine. 2016 Jun;52(3):571-8
pubmed: 26537478
Thyroid. 2016 Feb;26(2):197-202
pubmed: 26586610
Thyroid. 1991 Summer;1(3):241-8
pubmed: 1824339
Arzneimittelforschung. 2012 Dec;62(12):631-6
pubmed: 23154888
Clin Drug Investig. 2017 Jan;37(1):71-83
pubmed: 27798756
Horm Metab Res. 2006 Jan;38(1):57-9
pubmed: 16477543
Thyroid. 2008 May;18(5):493-8
pubmed: 18466075
Drugs R D. 2017 Mar;17(1):103-115
pubmed: 27943146
Arch Intern Med. 2010 Dec 13;170(22):1996-2003
pubmed: 21149757
Thyroid. 1995 Aug;5(4):249-53
pubmed: 7488863
Endocr Rev. 2014 Jun;35(3):433-512
pubmed: 24433025
Curr Opin Endocrinol Diabetes Obes. 2013 Oct;20(5):467-77
pubmed: 23974777
Acta Clin Belg. 2017 Feb;72(1):72-75
pubmed: 27362875
Aliment Pharmacol Ther. 2000 Nov;14(11):1383-401
pubmed: 11069309
Eur J Pharm Sci. 2014 Oct 1;62:96-104
pubmed: 24880112
Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):75-87
pubmed: 11259834
Gastroenterology. 2001 Feb;120(2):377-86
pubmed: 11159878
Eur J Pharm Biopharm. 2009 May;72(1):105-10
pubmed: 18996189
Int J Endocrinol. 2016;2016:9043450
pubmed: 27313613
Nat Rev Gastroenterol Hepatol. 2013 Sep;10(9):529-41
pubmed: 23774773
Endocrine. 2015 May;49(1):51-7
pubmed: 25595886
Expert Opin Drug Deliv. 2017 Apr;14(4):467-472
pubmed: 28151692
AAPS PharmSciTech. 2011 Sep;12(3):938-48
pubmed: 21748540
N Engl J Med. 2006 Apr 27;354(17):1787-95
pubmed: 16641395
Lancet. 1995 Jun 17;345(8964):1525-8
pubmed: 7791437
Thyroid. 2014 Dec;24(12):1670-751
pubmed: 25266247
Patient Prefer Adherence. 2016 Jul 27;10:1385-99
pubmed: 27528802
Clin Endocrinol (Oxf). 2004 Oct;61(4):405-13
pubmed: 15473869
Clin Immunol. 2017 Nov;184:42-47
pubmed: 28461108
Endocr Pract. 2014 Mar;20(3):e38-41
pubmed: 24246350
Best Pract Res Clin Endocrinol Metab. 2020 Jan;34(1):101373
pubmed: 31864909
Ther Drug Monit. 2011 Jun;33(3):355-61
pubmed: 21516059
Eur Endocrinol. 2013 Mar;9(1):40-47
pubmed: 30349610
Intern Emerg Med. 2016 Dec;11(8):1151-1152
pubmed: 27562380
Best Pract Res Clin Endocrinol Metab. 2009 Dec;23(6):781-92
pubmed: 19942153
World J Gastroenterol. 2008 Jan 28;14(4):563-8
pubmed: 18203288
JAMA. 2000 Jun 7;283(21):2822-5
pubmed: 10838651
Eur J Pharm Sci. 2017 Jan 1;96:207-231
pubmed: 27597144
Endocr Pract. 2012 Jan-Feb;18(1):98-100
pubmed: 21856591
Endocr Res. 1988;14(2-3):203-24
pubmed: 3049061
Endocr Rev. 2019 Feb 1;40(1):118-136
pubmed: 30476027
Metabolism. 1977 Jan;26(1):1-8
pubmed: 834138
J Pharmacol Exp Ther. 1957 Aug;120(4):540-5
pubmed: 13476378
J Clin Endocrinol Metab. 2014 Dec;99(12):4481-6
pubmed: 25259910
J Pharm Pharm Sci. 2015;18(5):844-55
pubmed: 26670370
Clin Exp Immunol. 2011 Aug;165(2):148-54
pubmed: 21623768
Endocrine. 2020 Feb;67(2):281-290
pubmed: 31953721
Thyroid. 2008 Mar;18(3):293-301
pubmed: 18341376
Drug Discov Today. 2013 Dec;18(23-24):1173-84
pubmed: 24042023
J Endocrinol Invest. 2017 Dec;40(12):1289-1301
pubmed: 28695483
BMC Gastroenterol. 2016 Feb 24;16:22
pubmed: 26965518
Endocrine. 2017 Sep;57(3):394-401
pubmed: 27848196
Endocr Pract. 2007 Jul-Aug;13(4):345-9
pubmed: 17669709
Endocrine. 2018 Jul;61(1):28-35
pubmed: 29572710
Pharm Res. 1992 Jan;9(1):131-7
pubmed: 1589398
Clin Endocrinol (Oxf). 2008 Apr;68(4):640-5
pubmed: 18062801
J La State Med Soc. 2015 Mar-Apr;167(2):47-9
pubmed: 25978052
Ann Clin Biochem. 2016 Jul;53(Pt 4):421-33
pubmed: 27126268
Helicobacter. 2011 Apr;16(2):124-30
pubmed: 21435090
Endocrine. 2017 Oct;58(1):143-152
pubmed: 28155170
Front Endocrinol (Lausanne). 2018 Jan 26;9:10
pubmed: 29434573
Angew Chem Int Ed Engl. 2015 Sep 7;54(37):10833-7
pubmed: 26213168
Obes Surg. 2018 Nov;28(11):3538-3543
pubmed: 30008061
Obes Surg. 2016 Oct;26(10):2538-42
pubmed: 27475799
J Clin Endocrinol Metab. 2009 Oct;94(10):3905-12
pubmed: 19584184
J Clin Med. 2019 Nov 15;8(11):
pubmed: 31731715
Clin Ther. 2017 Feb;39(2):378-403
pubmed: 28153426
N Engl J Med. 1965 Jul 8;273:83-7
pubmed: 14301203
Eur J Pharm Biopharm. 2004 Sep;58(2):265-78
pubmed: 15296954
Mol Pharm. 2013 Nov 4;10(11):3970-9
pubmed: 23844623
Surg Obes Relat Dis. 2019 Feb;15(2):333-341
pubmed: 30704913
Case Rep Endocrinol. 2016;2016:1316724
pubmed: 27293919
Obes Surg. 2016 Dec;26(12):2817-2823
pubmed: 27185177