Systemic Inflammation in Pregnant Women With Latent Tuberculosis Infection.
Adolescent
Adult
Antigens, CD
/ blood
Antigens, Differentiation, Myelomonocytic
/ blood
Cohort Studies
Cytokines
/ blood
Diabetes, Gestational
/ blood
Female
HIV Infections
/ blood
Humans
Inflammation
/ blood
Latent Tuberculosis
/ blood
Orosomucoid
/ analysis
Pregnancy
Receptors, Cell Surface
/ blood
Young Adult
LTBI
TB
cytokines
inflammation
latent tuberculosis infection
pregnancy
tuberculosis disease
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
07
2020
accepted:
09
12
2020
entrez:
15
2
2021
pubmed:
16
2
2021
medline:
17
7
2021
Statut:
epublish
Résumé
Recent studies in adults have characterized differences in systemic inflammation between adults with and without latent tuberculosis infection (LTBI+ We conducted a cohort study of 155 LTBI+ and 65 LTBI- pregnant women, stratified by HIV status, attending an antenatal clinic in Pune, India. LTBI status was assessed by interferon gamma release assay. Plasma was used to measure systemic inflammation markers using immunoassays: IFN Study population was a median age of 23 (Interquartile range: 21-27), 28% undernourished (mid-upper arm circumference (MUAC) <23 cm), 12% were vegetarian, 10% with gestational diabetes and 32% with HIV. In multivariable models, LTBI+ women had significantly lower levels of third trimester AGP, IL1β, sCD163, IL-6 and IL-17a. Interestingly, in exploratory analysis, LTBI+ TB progressors had significantly higher levels of IL1 Our data shows a distinct systemic immune profile in LTBI+ pregnant women compared to LTBI- women. Data from our exploratory analysis suggest that LTBI+ TB progressors do not have this immune profile, suggesting negative association of this profile with TB progression. If other studies confirm these differences by LTBI status and show a causal relationship with TB progression, this immune profile could identify subsets of LTBI+ pregnant women at high risk for TB progression and who can be targeted for preventative therapy.
Sections du résumé
Background
Recent studies in adults have characterized differences in systemic inflammation between adults with and without latent tuberculosis infection (LTBI+
Methods
We conducted a cohort study of 155 LTBI+ and 65 LTBI- pregnant women, stratified by HIV status, attending an antenatal clinic in Pune, India. LTBI status was assessed by interferon gamma release assay. Plasma was used to measure systemic inflammation markers using immunoassays: IFN
Results
Study population was a median age of 23 (Interquartile range: 21-27), 28% undernourished (mid-upper arm circumference (MUAC) <23 cm), 12% were vegetarian, 10% with gestational diabetes and 32% with HIV. In multivariable models, LTBI+ women had significantly lower levels of third trimester AGP, IL1β, sCD163, IL-6 and IL-17a. Interestingly, in exploratory analysis, LTBI+ TB progressors had significantly higher levels of IL1
Conclusions
Our data shows a distinct systemic immune profile in LTBI+ pregnant women compared to LTBI- women. Data from our exploratory analysis suggest that LTBI+ TB progressors do not have this immune profile, suggesting negative association of this profile with TB progression. If other studies confirm these differences by LTBI status and show a causal relationship with TB progression, this immune profile could identify subsets of LTBI+ pregnant women at high risk for TB progression and who can be targeted for preventative therapy.
Identifiants
pubmed: 33584652
doi: 10.3389/fimmu.2020.587617
pmc: PMC7873478
doi:
Substances chimiques
Antigens, CD
0
Antigens, Differentiation, Myelomonocytic
0
CD163 antigen
0
Cytokines
0
Orosomucoid
0
Receptors, Cell Surface
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
587617Subventions
Organisme : NICHD NIH HHS
ID : R00 HD089753
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD081929
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI069465
Pays : United States
Organisme : NIAID NIH HHS
ID : K23 AI129854
Pays : United States
Informations de copyright
Copyright © 2021 Naik, Alexander, Kumar, Kulkarni, Deshpande, Yadana, Leu, Araújo-Pereira, Andrade, Bhosale, Babu, Gupta, Mathad and Shivakoti.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer GW declared a past co-authorship with one of the authors BA to the handling editor.
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