A T-Cell Surface Marker Panel Predicts Murine Acute Graft-Versus-Host Disease.
Acute Disease
Animals
Antigens, CD
/ metabolism
Biomarkers
Biopsy
Disease Models, Animal
Disease Susceptibility
Female
Graft vs Host Disease
/ diagnosis
Hematopoietic Stem Cell Transplantation
/ adverse effects
Mice
Prognosis
T-Lymphocyte Subsets
/ immunology
T-Lymphocytes
/ immunology
Transplantation, Homologous
acute graft-versus-host disease
alloreactive T cells
mouse models
prediction
transplantation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
10
08
2020
accepted:
11
12
2020
entrez:
15
2
2021
pubmed:
16
2
2021
medline:
22
6
2021
Statut:
epublish
Résumé
Acute graft-versus-host disease (aGvHD) is a severe and often life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT). AGvHD is mediated by alloreactive donor T-cells targeting predominantly the gastrointestinal tract, liver, and skin. Recent work in mice and patients undergoing allo-HCT showed that alloreactive T-cells can be identified by the expression of α4β7 integrin on T-cells even before manifestation of an aGvHD. Here, we investigated whether the detection of a combination of the expression of T-cell surface markers on peripheral blood (PB) CD8
Identifiants
pubmed: 33584657
doi: 10.3389/fimmu.2020.593321
pmc: PMC7880247
doi:
Substances chimiques
Antigens, CD
0
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
593321Informations de copyright
Copyright © 2021 Bäuerlein, Qureischi, Mokhtari, Tabares, Brede, Jordán Garrote, Riedel, Chopra, Reu, Mottok, Arellano-Viera, Graf, Kurzwart, Schmiedgen, Einsele, Wölfl, Schlegel and Beilhack.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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