The Role of PTX3 in Mineralization Processes and Aging-Related Bone Diseases.
PTX3
aging
bone diseases
ectopic calcification
fracture healing
inflammation
mineralization
osteoporosis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
10
2020
accepted:
16
12
2020
entrez:
15
2
2021
pubmed:
16
2
2021
medline:
24
6
2021
Statut:
epublish
Résumé
The Long Pentraxin 3 (PTX3) is a multifunctional glycoprotein released by peripheral blood leukocytes and myeloid dendritic cells in response to primary pro-inflammatory stimuli, that acts as a non-redundant component of the humoral arm of innate immunity. In addition to the primary role in the acute inflammatory response, PTX3 seems to be involved in other physiological and pathological processes. Indeed, PTX3 seems to play a pivotal role in the deposition and remodeling of bone matrix during the mineralization process, promoting osteoblasts differentiation and activity. Recently, PTX3 was seen to be involved in the ectopic calcifications' formation in breast cancer disease. In this regard, it has been observed that breast cancer tumors characterized by high expression of PTX3 and high amount of Breast Osteoblast Like Cells (BOLCs) showed several Hydroxyapatite (HA) microcalcifications, suggesting a likely role for PTX3 in differentiation and osteoblastic activity in both bone and extra-bone sites. Furthermore, given its involvement in bone metabolism, several studies agree with the definition of PTX3 as a molecule significantly involved in the pathogenesis of age-related bone diseases, such as osteoporosis, both in mice and humans. Recent results suggest that genetic and epigenetic mechanisms acting on
Identifiants
pubmed: 33584725
doi: 10.3389/fimmu.2020.622772
pmc: PMC7878364
doi:
Substances chimiques
Nerve Tissue Proteins
0
Serum Amyloid P-Component
0
neuronal pentraxin
0
PTX3 protein
148591-49-5
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
622772Informations de copyright
Copyright © 2021 Tarantino, Greggi, Cariati, Visconti, Gasparini, Cateni, Gasbarra, Botta, Salustri and Scimeca.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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