Case Report: B Lymphocyte Disorders Under COVID-19 Inflammatory Pressure.
B-cell lineage malignancies
COVID-19
acute lymphoblastic leukemia
autoimmune hemolytic anemia
multiple myeloma
reactivation
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
07
2020
accepted:
23
11
2020
entrez:
15
2
2021
pubmed:
16
2
2021
medline:
16
2
2021
Statut:
epublish
Résumé
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects humans through the angiotensin converting enzyme-2 (ACE-2) receptor expressed on many cells, including lymphocytes. In Covid-19 patients IL-6 is overexpressed, and hyperactivated plasmacytoid lymphocytes are detected in peripheral blood film. We hypothesize that, due to the unpredictable interaction between the new virus and the B cell lineage of infected patients, a cascade of out of control events can ensue, capable of determining unexpected pathologic disorders involving such lineage. Here we report two cases of autoimmune hemolytic anemia (AIHA) and two cases of B-cell hematological malignancies developed or reactivated during acute SARS-CoV-2 infection. The temporal relationship of the events may suggest a potential causal relationship between SARS-CoV-2 infection and the hematopoietic disorders. We suggest that special attention should be paid to COVID-19 patients with underlining B cell lineage disorders.
Identifiants
pubmed: 33585201
doi: 10.3389/fonc.2020.582901
pmc: PMC7874205
doi:
Types de publication
Case Reports
Langues
eng
Pagination
582901Investigateurs
Daniela Aschieri
(D)
Mario Barbera
(M)
Carlo Cagnoni
(C)
Luigi Cavanna
(L)
Cosimo Franco
(C)
Chiara Gorrini
(C)
Andrea Magnacavallo
(A)
Massimo Nolli
(M)
Massimo Piepoli
(M)
Roberta Schiavo
(R)
Matteo Silva
(M)
Marco Stabile
(M)
Angela Rossi
(A)
Giovanni Vadacca
(G)
Informations de copyright
Copyright © 2021 Taliani, Follini, Guglielmetti, Bernuzzi, Faggi, Ferrante, Fronti, Gerna, Leoni, Paolillo, Ratti, Ruggieri, Valdatta, Donisi, Zangrandi, Pochintesta, Moroni, Sacchini, Vallisa, Codeluppi and the COVID-Piacenza Group.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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