Evolution of Experimental Models in the Study of Glioblastoma: Toward Finding Efficient Treatments.
3D bioprinting
brain organoids
cell cultures of glioma cells
glioma stem cells
mouse models of glioblastoma
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
05
10
2020
accepted:
14
12
2020
entrez:
15
2
2021
pubmed:
16
2
2021
medline:
16
2
2021
Statut:
epublish
Résumé
Glioblastoma (GBM) is the most common form of brain tumor characterized by its resistance to conventional therapies, including temozolomide, the most widely used chemotherapeutic agent in the treatment of GBM. Within the tumor, the presence of glioma stem cells (GSC) seems to be the reason for drug resistance. The discovery of GSC has boosted the search for new experimental models to study GBM, which allow the development of new GBM treatments targeting these cells. In here, we describe different strategies currently in use to study GBM. Initial GBM investigations were focused in the development of xenograft assays. Thereafter, techniques advanced to dissociate tumor cells into single-cell suspensions, which generate aggregates referred to as neurospheres, thus facilitating their selective expansion. Concomitantly, the finding of genes involved in the initiation and progression of GBM tumors, led to the generation of mice models for the GBM. The latest advances have been the use of GBM organoids or 3D-bioprinted mini-brains. 3D bio-printing mimics tissue cytoarchitecture by combining different types of cells interacting with each other and with extracellular matrix components. These
Identifiants
pubmed: 33585240
doi: 10.3389/fonc.2020.614295
pmc: PMC7878535
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
614295Informations de copyright
Copyright © 2021 Gómez-Oliva, Domínguez-García, Carrascal, Abalos-Martínez, Pardillo-Díaz, Verástegui, Castro, Nunez-Abades and Geribaldi-Doldán.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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