Case Report: Testicular Sarcoidosis: The Diagnostic Role of Contrast-Enhanced Ultrasound and Review of the Literature.
andrology
contrast media
sarcoidosis
ultrasonography
urology
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2020
2020
Historique:
received:
25
09
2020
accepted:
18
12
2020
entrez:
15
2
2021
pubmed:
16
2
2021
medline:
16
2
2021
Statut:
epublish
Résumé
Sarcoidosis is a multisystemic disease histologically characterized by non-caseating epithelioid granulomas and multinucleated giant cells; the etiology is still uncertain, and likely related to a complex interplay between environmental and genetic factors. The genitourinary system is affected in fewer than 0.2% of all clinically diagnosed cases of sarcoidosis and in 5% of those identified in autopsy studies. In this report, we describe a case of a 42-year-old male with one hypoechoic lesion per testis on B-mode evaluation; contrast-enhanced ultrasound (CEUS) on both lesions was carried out. During the early phase, the masses showed a hypovascular appearance as compared to the surrounding testicular tissue, maintaining the hypo-enhancement in the late phase. Tissue biopsy for pathological evaluation confirmed testicular sarcoid involvement, showing non-caseating granulomas. Allowing visualization of testicular microvascularisation, CEUS may play an important role in excluding malignancy, avoiding unnecessary aggressive treatment for benign conditions, such as sarcoidosis. A review of the literature of reported cases since 2004 of sarcoidosis involving the testis is also included.
Identifiants
pubmed: 33585510
doi: 10.3389/fmed.2020.610384
pmc: PMC7873883
doi:
Types de publication
Case Reports
Langues
eng
Pagination
610384Informations de copyright
Copyright © 2021 De Cinque, Corcioni, Rossi, Franceschelli, Colombo, Golfieri, Renzulli and Gaudiano.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Ther Adv Chronic Dis. 2018 Aug 24;9(11):227-240
pubmed: 30364496
Ann Am Thorac Soc. 2016 Aug;13(8):1244-52
pubmed: 27509154
J Androl. 2012 Mar-Apr;33(2):162-6
pubmed: 21546613
Clin Radiol. 2007 Apr;62(4):289-302
pubmed: 17331822
Indian J Urol. 2011 Apr;27(2):269-71
pubmed: 21814320
J Clin Ultrasound. 1999 Feb;27(2):81-3
pubmed: 9932253
Clin Nucl Med. 2020 Aug;45(8):e368-e369
pubmed: 32558707
Endocr Rev. 2019 Aug 1;40(4):973-987
pubmed: 30882882
Clin Chest Med. 2008 Sep;29(3):391-414, viii
pubmed: 18539234
Cent European J Urol. 2014;67(3):261-3
pubmed: 25247084
Int J Urol. 2004 May;11(5):345-8
pubmed: 15147556
Urology. 2006 Jan;67(1):200
pubmed: 16413374
Ann R Coll Surg Engl. 2019 Apr;101(4):e99-e101
pubmed: 30907629
Korean J Urol. 2011 Apr;52(4):295-7
pubmed: 21556220
Clin Chest Med. 2008 Sep;29(3):379-90, vii
pubmed: 18539233
Urol Case Rep. 2018 Feb 03;17:109-110
pubmed: 29552500
Rev Col Bras Cir. 2011 Mar-Apr;38(2):145-6
pubmed: 21710056
J Urol. 1989 Oct;142(4):1003-5
pubmed: 2677407
Thorax. 2006 Nov;61(11):980-5
pubmed: 16844727
Int J Urol. 2019 Nov;26(11):1079-1081
pubmed: 31379006
Intern Med. 2003 Jan;42(1):92-7
pubmed: 12583627
J Reprod Med. 2017 Mar-Apr;62(3-4):204-6
pubmed: 30230796
Arch Ital Urol Androl. 2014 Dec 30;86(4):389-90
pubmed: 25641479
Respir Res. 2018 Aug 28;19(1):158
pubmed: 30153830
Eur Respir J. 2016 Dec;48(6):1690-1699
pubmed: 27471207
BMJ Case Rep. 2013 Feb 15;2013:
pubmed: 23417949
J Hepatol. 2018 Jul;69(1):182-236
pubmed: 29628281
Sarcoidosis Vasc Diffuse Lung Dis. 2007 Sep;24(2):95-101
pubmed: 18496978
Fertil Steril. 2004 Dec;82(6):1672-4
pubmed: 15589877
Rev Med Interne. 2019 Jul;40(7):476-477
pubmed: 30309691
J Ultrasound Med. 2016 Jul;35(7):1593-9
pubmed: 27335443
Radiology. 2014 Nov;273(2):606-18
pubmed: 24968192
IJU Case Rep. 2019 Oct 19;3(1):12-14
pubmed: 32743456
Urology. 2005 Sep;66(3):657
pubmed: 16140105
Am J Respir Crit Care Med. 2001 Nov 15;164(10 Pt 1):1885-9
pubmed: 11734441
J Ultrasound Med. 2017 Feb;36(2):409-420
pubmed: 28032907
Semin Ultrasound CT MR. 2013 Jun;34(3):257-73
pubmed: 23768892
Am J Respir Crit Care Med. 2004 Dec 15;170(12):1324-30
pubmed: 15347561
BJU Int. 2012 Oct;110(8):1102-9
pubmed: 22429248
Urology. 2011 May;77(5):1049-53
pubmed: 21334049
Lung. 2017 Feb;195(1):87-91
pubmed: 27709291
Ultraschall Med. 2018 Apr;39(2):e2-e44
pubmed: 29510439
Case Rep Oncol. 2011 Mar 02;4(1):118-24
pubmed: 21475601
J Clin Oncol. 2008 Dec 20;26(36):6007-8
pubmed: 19029414
Radiographics. 2018 Sep-Oct;38(5):1536-1549
pubmed: 30118393
Urol Ann. 2015 Jul-Sep;7(3):378-9
pubmed: 26229331
Abdom Radiol (NY). 2018 Apr;43(4):899-917
pubmed: 29460046