Nuclease resistance of DNA nanostructures.

DNA DNA nanostructures Nanobiotechnology

Journal

Nature reviews. Chemistry

ISSN: 2397-3358

Titre abrégé: Nat Rev Chem

Pays: England

ID NLM: 101703631

Informations de publication

Date de publication:
2021

Historique:

accepted: 08 01 2021

pubmed: 16 2 2021

medline: 16 2 2021

entrez: 15 2 2021

Statut: ppublish

Résumé

DNA nanotechnology has progressed from proof-of-concept demonstrations of structural design towards application-oriented research. As a natural material with excellent self-assembling properties, DNA is an indomitable choice for various biological applications, including biosensing, cell modulation, bioimaging and drug delivery. However, a major impediment to the use of DNA nanostructures in biological applications is their susceptibility to attack by nucleases present in the physiological environment. Although several DNA nanostructures show enhanced resistance to nuclease attack compared with duplexes and plasmid DNA, this may be inadequate for practical application. Recently, several strategies have been developed to increase the nuclease resistance of DNA nanostructures while retaining their functions, and the stability of various DNA nanostructures has been studied in biological fluids, such as serum, urine and cell lysates. This Review discusses the approaches used to modulate nuclease resistance in DNA nanostructures and provides an overview of the techniques employed to evaluate resistance to degradation and quantify stability.

Identifiants

DOI: 10.1038/s41570-021-00251-y PMID: 33585701 PMC: PMC7873672

pubmed: 33585701

doi: 10.1038/s41570-021-00251-y

pii: 251

pmc: PMC7873672

doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

225-239

Informations de copyright

Déclaration de conflit d'intérêts

Competing interestsThe author declares no competing interests.

Références

Nanoscale Adv. 2019 Mar 1;1(3):969-972

pubmed: 31179419

J Am Chem Soc. 2014 Apr 23;136(16):5836-9

pubmed: 24716858

Science. 2009 Aug 7;325(5941):725-30

pubmed: 19661424

Biomed Phys Eng Express. 2020 Nov 24;6(6):

pubmed: 35114660

Biomacromolecules. 2014 Jan 13;15(1):276-82

pubmed: 24328173

Nat Nanotechnol. 2009 Sep;4(9):557-61

pubmed: 19734926

Angew Chem Int Ed Engl. 2017 May 8;56(20):5460-5464

pubmed: 28295864

Nat Nanotechnol. 2013 Feb;8(2):137-43

pubmed: 23334168

Angew Chem Int Ed Engl. 2004 Jul 5;43(27):3550-3

pubmed: 15293242

Nat Biotechnol. 2005 Jul;23(7):885-9

pubmed: 15951805

Science. 2005 Dec 9;310(5754):1661-5

pubmed: 16339440

Science. 2015 Feb 20;347(6224):1260901

pubmed: 25700524

ACS Nano. 2014 May 27;8(5):5132-40

pubmed: 24694301

Angew Chem Int Ed Engl. 2015 Jun 26;54(27):7795-8

pubmed: 25980669

Trends Biotechnol. 2015 Oct;33(10):586-594

pubmed: 26409777

Chem Rev. 2017 Oct 25;117(20):12584-12640

pubmed: 28605177

ACS Nano. 2013 Nov 26;7(11):9724-34

pubmed: 24168393

ACS Appl Bio Mater. 2020 Nov 16;3(11):7265-7277

pubmed: 35019470

Sci Adv. 2018 Aug 17;4(8):eaau1157

pubmed: 30128357

Nat Commun. 2011 Jun 07;2:339

pubmed: 21654639

Trends Biochem Sci. 2018 Dec;43(12):997-1013

pubmed: 30342801

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7456-E7463

pubmed: 27821763

Nature. 2015 Jul 23;523(7561):441-4

pubmed: 26201596

Nano Lett. 2015 Jan 14;15(1):603-9

pubmed: 25546084

Arch Biochem Biophys. 1953 Mar;43(1):97-107

pubmed: 13031664

Nanoscale. 2016 Oct 14;8(40):17542-17550

pubmed: 27714127

Chem Commun (Camb). 2015 Apr 4;51(26):5747-50

pubmed: 25720373

J Control Release. 2016 Oct 10;239:27-38

pubmed: 27527555

Small. 2016 May;12(20):2689-700

pubmed: 27040036

Nature. 2008 Mar 13;452(7184):198-201

pubmed: 18337818

Sci Adv. 2019 Jan 04;5(1):eaav0655

pubmed: 30613779

ACS Nano. 2014 Sep 23;8(9):8765-75

pubmed: 25136758

J Am Chem Soc. 2010 Oct 27;132(42):14727-9

pubmed: 20925350

Lab Chip. 2019 May 14;19(10):1747-1754

pubmed: 30964485

Nanoscale. 2016 Feb 28;8(8):4436-46

pubmed: 26852879

Angew Chem Int Ed Engl. 2012 Sep 3;51(36):9020-4

pubmed: 22887892

Angew Chem Int Ed Engl. 2018 Jun 4;57(23):6892-6895

pubmed: 29683548

Angew Chem Int Ed Engl. 2009;48(23):4134-7

pubmed: 19222079

Science. 2004 Dec 17;306(5704):2072-4

pubmed: 15604403

Nanoscale. 2020 Nov 5;12(42):21583-21590

pubmed: 33089274

Nano Lett. 2013 Sep 11;13(9):4242-8

pubmed: 23978049

Nature. 2010 May 13;465(7295):202-5

pubmed: 20463734

Nano Lett. 2012 Aug 8;12(8):4254-9

pubmed: 22746330

J Am Chem Soc. 2017 May 31;139(21):7355-7362

pubmed: 28475327

Proc Natl Acad Sci U S A. 1989 Dec;86(23):9273-7

pubmed: 2594767

Angew Chem Int Ed Engl. 2014 Jun 2;53(23):5821-6

pubmed: 24753303

ACS Nano. 2022 Jun 28;16(6):8954-8966

pubmed: 35640255

Nanoscale. 2016 May 21;8(19):10398-405

pubmed: 27142120

Nanomedicine. 2018 Feb 17;14(4):1227-1236

pubmed: 29458214

Biopolymers. 1997;44(4):405-21

pubmed: 9782777

Nucleic Acids Res. 2018 Jan 25;46(2):995-1006

pubmed: 29216375

Annu Rev Biochem. 2001;70:369-413

pubmed: 11395412

Annu Rev Biochem. 2006;75:567-605

pubmed: 16756503

Anal Chem. 2019 Dec 3;91(23):15107-15113

pubmed: 31691558

Curr Protoc Nucleic Acid Chem. 2020 Sep;82(1):e115

pubmed: 32931657

Nucleic Acids Res. 1991 Feb 25;19(4):747-50

pubmed: 1850122

Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6339-6348

pubmed: 32165539

Cell Prolif. 2017 Oct;50(5):

pubmed: 28792637

J Am Chem Soc. 2020 Apr 8;142(14):6814-6821

pubmed: 32208657

Nat Nanotechnol. 2009 May;4(5):325-30

pubmed: 19421220

J Am Chem Soc. 2011 Sep 21;133(37):14488-91

pubmed: 21859143

Int J Mol Sci. 2018 Aug 24;19(9):

pubmed: 30149587

Adv Healthc Mater. 2019 May;8(9):e1801546

pubmed: 30843670

Chem Commun (Camb). 2019 Aug 21;55(65):9709-9712

pubmed: 31353371

Nature. 2006 Mar 16;440(7082):297-302

pubmed: 16541064

Science. 2011 Jun 3;332(6034):1196-201

pubmed: 21636773

Nano Lett. 2020 Mar 11;20(3):1477-1478

pubmed: 32011893

Sci Adv. 2019 Mar 13;5(3):eaau9443

pubmed: 30891499

ACS Appl Mater Interfaces. 2018 Jan 31;10(4):3421-3430

pubmed: 29300456

J Am Chem Soc. 2005 Sep 7;127(35):12202-3

pubmed: 16131180

Chem Rev. 2019 Nov 27;119(22):11631-11717

pubmed: 31573184

Nanoscale. 2017 Jun 14;9(23):7750-7754

pubmed: 28581004

Annu Rev Anal Chem (Palo Alto Calif). 2018 Jun 12;11(1):171-195

pubmed: 29490188

Nanoscale. 2015 Jun 21;7(23):10382-90

pubmed: 25959862

ACS Sens. 2017 Jun 23;2(6):735-739

pubmed: 28723114

Nano Lett. 2019 Jun 12;19(6):3751-3760

pubmed: 31140279

Chem Commun (Camb). 2013 Feb 11;49(12):1172-4

pubmed: 23287884

Nature. 2003 Jan 23;421(6921):427-31

pubmed: 12540916

Science. 2012 Feb 17;335(6070):831-4

pubmed: 22344439

Angew Chem Int Ed Engl. 2020 Jan 7;59(2):700-703

pubmed: 31595637

Nat Nanotechnol. 2011 Nov 06;6(12):763-72

pubmed: 22056726

Nature. 2000 Aug 10;406(6796):605-8

pubmed: 10949296

J Am Chem Soc. 2020 Feb 19;142(7):3311-3315

pubmed: 32011869

Q Rev Biophys. 2011 Feb;44(1):1-93

pubmed: 20854710

Nat Commun. 2017 May 31;8:15654

pubmed: 28561045

ACS Appl Bio Mater. 2020 Jul 20;3(7):3928-3934

pubmed: 35025469

Proc Biol Sci. 2012 Dec 7;279(1748):4724-33

pubmed: 23055061

Science. 2012 Nov 30;338(6111):1177-83

pubmed: 23197527

ACS Cent Sci. 2019 May 22;5(5):882-891

pubmed: 31139724

Chemistry. 2019 Jul 5;25(38):9012-9016

pubmed: 31081977

Angew Chem Int Ed Engl. 2018 Jul 20;57(30):9470-9474

pubmed: 29799663

Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6644-8

pubmed: 17404217

Nucleic Acids Res. 2019 Nov 18;47(20):10489-10505

pubmed: 31287874

Exp Anim. 1995 Apr;44(2):169-71

pubmed: 7601228

Chem Commun (Camb). 2019 Jun 11;55(46):6587-6590

pubmed: 31116197

Nanotechnology. 2018 Feb 9;29(6):062001

pubmed: 29232197

Nanoscale. 2018 Apr 26;10(16):7494-7504

pubmed: 29637957

Nat Rev Mol Cell Biol. 2005 Sep;6(9):677-88

pubmed: 16103871

Chembiochem. 2016 Jun 16;17(12):1081-9

pubmed: 26928725

Nature. 2009 May 7;459(7243):73-6

pubmed: 19424153

Nano Lett. 2009 Jan;9(1):433-6

pubmed: 19063615

Chembiochem. 2019 Nov 18;20(22):2818-2823

pubmed: 31163091

Chemphyschem. 2017 Nov 3;18(21):2977-2980

pubmed: 28856771

Nat Methods. 2011 Mar;8(3):221-9

pubmed: 21358626

Angew Chem Int Ed Engl. 2014 Jul 21;53(30):7745-50

pubmed: 24827912

ACS Appl Mater Interfaces. 2016 May 25;8(20):12733-9

pubmed: 27153101

Chem Commun (Camb). 2009 Dec 7;(45):7036-8

pubmed: 19904386

Sci Adv. 2020 Sep 25;6(39):

pubmed: 32978154

Nat Protoc. 2014;9(6):1367-91

pubmed: 24833175

Chem Rev. 2019 May 22;119(10):6459-6506

pubmed: 29465222

Curr Opin Biotechnol. 2013 Aug;24(4):555-61

pubmed: 23566376

Nanoscale. 2016 Jun 2;8(22):11674-80

pubmed: 27219684

Talanta. 2018 Mar 1;179:356-363

pubmed: 29310244

Nano Lett. 2021 Jan 13;21(1):469-475

pubmed: 33395311

Science. 2014 Nov 7;346(6210):1258361

pubmed: 25301973

Chem Commun (Camb). 2017 Jun 29;53(53):7393-7396

pubmed: 28617516

Hum Gene Ther. 1999 Oct 10;10(15):2461-80

pubmed: 10543612

J Theor Biol. 1982 Nov 21;99(2):237-47

pubmed: 6188926

Nucleic Acids Res. 2020 May 21;48(9):4672-4680

pubmed: 32043111

Cell Chem Biol. 2017 Nov 16;24(11):1401-1406.e2

pubmed: 28988948

Nature. 1998 Aug 6;394(6693):539-44

pubmed: 9707114

Molecules. 2020 Jan 16;25(2):

pubmed: 31963295

Nat Biotechnol. 2018 Mar;36(3):258-264

pubmed: 29431737

J Am Chem Soc. 2019 Mar 13;141(10):4248-4251

pubmed: 30827097

Nature. 2017 Dec 6;552(7683):67-71

pubmed: 29219965

J Am Chem Soc. 2004 Oct 20;126(41):13240-1

pubmed: 15479075

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13600-13605

pubmed: 27856755

Chem Rev. 2019 May 22;119(10):6273-6289

pubmed: 29911864

ACS Nano. 2011 Dec 27;5(12):9696-702

pubmed: 22092186

J Am Chem Soc. 2018 Jan 24;140(3):947-953

pubmed: 29313682

Adv Healthc Mater. 2017 Sep;6(18):

pubmed: 28738444

Science. 2017 Mar 3;355(6328):950-954

pubmed: 28254941

Nat Methods. 2014 Mar;11(3):313-8

pubmed: 24487583

Annu Rev Biochem. 2016 Jun 2;85:349-73

pubmed: 27294440

Nat Rev Mol Cell Biol. 2003 Dec;4(12):960-70

pubmed: 14685174