Enhanced Osteoinductivity of Demineralized Bone Matrix with Noggin Suppression in Polymer Matrix.

Animals Bone Matrix Hydrogels Mesenchymal Stem Cells Mice Osteogenesis Polymers
DBM Hydrogel Noggin suppression Osteoinductivity

Journal

Advanced biology
ISSN: 2701-0198
Titre abrégé: Adv Biol (Weinh)
Pays: Germany
ID NLM: 101775319

Informations de publication

Date de publication:
01 2021
Historique:
entrez: 15 2 2021
pubmed: 16 2 2021
medline: 26 10 2021
Statut: ppublish

Résumé

Demineralized bone matrix (DBM), a potential alternative to autologous bone-graft, has been increasingly used for clinical bone repair; however, its application in larger defects isn't successful partly due to the rapid dispersion of DBM particles and relatively lower osteoinductivity. Here, a novel strategy is created to complement the osteoinductivity of DBM by incorporating DBM in biopolymer hydrogel combined with the abrogation of BMP antagonism. Combined treatment of DBM + noggin-suppression displays increased osteogenic potency of human bone marrow mesenchymal stem cells (hBMSCs)

Identifiants

DOI: 10.1002/adbi.202000135 PMID: 33585837 PMC: PMC7877805
pubmed: 33585837
doi: 10.1002/adbi.202000135
pmc: PMC7877805
mid: NIHMS1668350
pii:
doi:

Substances chimiques

Hydrogels 0
Polymers 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202000135

Subventions

Organisme : NIDCR NIH HHS
ID : R01 DE027332
Pays : United States

Déclaration de conflit d'intérêts

Conflict of Interest The authors indicated no potential conflicts of interest.

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Auteurs

Chen Chen (C)

Division of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095-1668, USA.

Matthew Rehnama (M)

Division of Advanced Prosthodontics, University of California, Los Angeles, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095-1668, USA.

Soyon Kim (S)

Division of Advanced Prosthodontics, University of California, Los Angeles, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095-1668, USA.

Chung-Sung Lee (CS)

Division of Advanced Prosthodontics, University of California, Los Angeles, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095-1668, USA.

Xiao Zhang (X)

Division of Advanced Prosthodontics, University of California, Los Angeles, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095-1668, USA.

Tara Aghaloo (T)

Division of Diagnostic and Surgical Sciences, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, California 90095, United States.

Jiabing Fan (J)

Division of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095-1668, USA.

Min Lee (M)

Division of Advanced Prosthodontics, School of Dentistry, Department of Bioengineering, University of California, Los Angeles, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095-1668, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Enhanced Osteoinductivity of Demineralized...
questionsmedicales.fr › Tissus › Tissu conjonctif › Os et tissu osseux › Trame osseuse › Enhanced Osteoinductivity of Demineralized...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Gels › Hydrogels › Enhanced Osteoinductivity of Demineralized...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Enhanced Osteoinductivity of Demineralized...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Enhanced Osteoinductivity of Demineralized...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Biominéralisation › Développement osseux › Ostéogenèse › Enhanced Osteoinductivity of Demineralized...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Enhanced Osteoinductivity of Demineralized...