Taurine supplementation reduces myeloperoxidase and matrix-metalloproteinase-9 levels and improves the effects of exercise in cognition and physical fitness in older women.
Aging
Cognition
Exercise
Immunity
Oxidative stress
Taurine
Journal
Amino acids
ISSN: 1438-2199
Titre abrégé: Amino Acids
Pays: Austria
ID NLM: 9200312
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
09
11
2020
accepted:
02
02
2021
pubmed:
16
2
2021
medline:
29
10
2021
entrez:
15
2
2021
Statut:
ppublish
Résumé
Immunosenescence contributes to cognitive impairment and neurodegeneration, and those conditions could be attenuated by non-pharmacological anti-inflammatory strategies, such as exercise and supplementation with the amino acid taurine. Since taurine body content decreases with aging, we investigated the effects of supplementation (alone and combined with exercise) on oxidative stress, extracellular matrix degradation, white blood cells, neurotrophins, cognition and physical fitness of elderly women. Forty-eight women (83.58 ± 6.98 years) were enrolled into exercise training only (EO: n = 13), taurine supplementation (TS: n = 12), exercise training + taurine supplementation (ETTS: n = 11), and control group (CG: n = 12). All interventions lasted 14 weeks. Exercise was applied twice a week, and taurine was given once a day (1.5 g). Data collection occurred before and after interventions with the determination of myeloperoxidase (MPO), matrix metalloproteinase-9 (MMP-9), brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) levels, and white blood cell counts (WBC). Montreal cognitive assessment (MoCA) and physical fitness tests were also evaluated. Concentration of MPO and MMP-9 decreased after intervention in TS (p < 0.05). No effect of time or time × group was observed for WBC parameters; however, univariate analysis showed a significant decrease in lymphocytes for TS, while an increase in monocytes occurred in the CG (p < 0.05). MoCA scores decreased over time in the CG (p < 0.05). Improvements in physical fitness occurred in ETTS (better agility and aerobic capacity), mostly likely due to exercise and boosted by taurine supplementation. No changes in BDNF levels were observed (p > 0.05), while NGF concentration were undetectable in almost subjects. Exercise together with taurine supplementation appears to be a valuable strategy to enhance health-related outcomes in older persons.
Identifiants
pubmed: 33586039
doi: 10.1007/s00726-021-02952-6
pii: 10.1007/s00726-021-02952-6
doi:
Substances chimiques
Taurine
1EQV5MLY3D
MPO protein, human
EC 1.11.1.7
Peroxidase
EC 1.11.1.7
MMP9 protein, human
EC 3.4.24.35
Matrix Metalloproteinase 9
EC 3.4.24.35
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
333-345Subventions
Organisme : Fundação para a Ciência e a Tecnologia
ID : PTDC/DTP-DES/0154/2012
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 13642-13/8
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 1417/3-4
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 11929-13/8
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