α-Synuclein plasma membrane localization correlates with cellular phosphatidylinositol polyphosphate levels.
A2780
HeLa
SH-SY5Y
SK-MEL-2
human cell lines
neuroscience
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
15 02 2021
15 02 2021
Historique:
received:
10
08
2020
accepted:
12
02
2021
pubmed:
16
2
2021
medline:
1
2
2022
entrez:
15
2
2021
Statut:
epublish
Résumé
The Parkinson's disease protein α-synuclein (αSyn) promotes membrane fusion and fission by interacting with various negatively charged phospholipids. Despite postulated roles in endocytosis and exocytosis, plasma membrane (PM) interactions of αSyn are poorly understood. Here, we show that phosphatidylinositol 4,5-bisphosphate (PIP
Identifiants
pubmed: 33587036
doi: 10.7554/eLife.61951
pii: 61951
pmc: PMC7929559
doi:
pii:
Substances chimiques
Phosphatidylinositol 4,5-Diphosphate
0
Phosphatidylinositol Phosphates
0
alpha-Synuclein
0
phosphatidylinositol 3,4,5-triphosphate
0
Phosphatidylinositol 3-Kinase
EC 2.7.1.137
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021, Jacob et al.
Déclaration de conflit d'intérêts
RJ, CE, AD, DM, PS No competing interests declared
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