Molecular Basis of Coupled Transport and Anion Conduction in Excitatory Amino Acid Transporters.

Amino Acid Transport System X-AG / metabolism Animals Anions / metabolism Biological Transport Excitatory Amino Acid Transporter 1 / metabolism Glutamate Plasma Membrane Transport Proteins / metabolism Glutamic Acid / metabolism Mammals / metabolism
Conformational selection Coupled transport Dual function protein EAAT anion channel Fluorescence spectroscopy GltPh Glutamate transporter Hairpin 2 Induced fit MD simulations Transport stoichiometry Tryptophan

Journal

Neurochemical research
ISSN: 1573-6903
Titre abrégé: Neurochem Res
Pays: United States
ID NLM: 7613461

Informations de publication

Date de publication:
Jan 2022
Historique:
received: 05 11 2020
accepted: 19 01 2021
revised: 18 01 2021
pubmed: 16 2 2021
medline: 1 4 2022
entrez: 15 2 2021
Statut: ppublish

Résumé

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system. After its release from presynaptic nerve terminals, glutamate is quickly removed from the synaptic cleft by excitatory amino acid transporters (EAATs) 1-5, a subfamily of glutamate transporters. The five proteins utilize a complex transport stoichiometry that couples glutamate transport to the symport of three Na

Identifiants

DOI: 10.1007/s11064-021-03252-x PMID: 33587237 PMC: PMC8763778
pubmed: 33587237
doi: 10.1007/s11064-021-03252-x
pii: 10.1007/s11064-021-03252-x
pmc: PMC8763778
doi:

Substances chimiques

Amino Acid Transport System X-AG 0
Anions 0
Excitatory Amino Acid Transporter 1 0
Glutamate Plasma Membrane Transport Proteins 0
Glutamic Acid 3KX376GY7L

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

9-22

Subventions

Organisme : Verein Deutscher Ingenieure
ID : FA 301/12-2
Organisme : Verein Deutscher Ingenieure
ID : MA 7525/1-2

Informations de copyright

© 2021. The Author(s).

Références

Biophys J. 1996 Feb;70(2):733-42
pubmed: 8789090
Nat Struct Mol Biol. 2018 Jun;25(6):515-521
pubmed: 29872227
Nature. 1992 Dec 3;360(6403):467-71
pubmed: 1280334
J Gen Physiol. 2020 Oct 5;152(10):
pubmed: 32835376
J Biol Chem. 1996 Nov 8;271(45):27991-4
pubmed: 8910405
Neurology. 2005 Aug 23;65(4):529-34
pubmed: 16116111
Biochemistry. 1982 Jun 22;21(13):3143-7
pubmed: 6125209
Nature. 2013 Oct 3;502(7469):119-23
pubmed: 24091978
Biochemistry. 2005 Sep 6;44(35):11913-23
pubmed: 16128593
J Neurosci. 2000 Apr 15;20(8):2749-57
pubmed: 10751425
Glia. 2017 Feb;65(2):388-400
pubmed: 27859594
Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4155-60
pubmed: 9108121
Neuron. 1995 Sep;15(3):721-8
pubmed: 7546750
FEBS Lett. 1978 Oct 15;94(2):245-8
pubmed: 700148
Eur J Med Genet. 2016 Aug;59(8):373-6
pubmed: 27296938
Biochemistry. 1978 Sep 19;17(19):3949-53
pubmed: 708689
J Neurosci. 2015 Apr 1;35(13):5187-201
pubmed: 25834045
Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12761-6
pubmed: 17652169
Nat Commun. 2016 Nov 10;7:13420
pubmed: 27830699
Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10955-9
pubmed: 1279699
EMBO J. 2019 Oct 1;38(19):e101468
pubmed: 31506973
J Neurosci. 2002 Dec 1;22(23):10153-62
pubmed: 12451116
Neuron. 1995 May;14(5):1019-27
pubmed: 7748550
Elife. 2014 May 19;3:e02283
pubmed: 24842876
J Neurosci. 2007 Mar 14;27(11):2938-42
pubmed: 17360916
Hum Mol Genet. 2018 Aug 1;27(15):2614-2627
pubmed: 29741614
Nat Neurosci. 2006 Nov;9(11):1388-96
pubmed: 17041592
Am J Hum Genet. 2017 Aug 3;101(2):300-310
pubmed: 28777935
Nature. 2009 Dec 17;462(7275):880-5
pubmed: 19924125
J Biol Chem. 2011 Jul 8;286(27):23780-8
pubmed: 21572047
Nature. 2007 Jan 25;445(7126):387-93
pubmed: 17230192
Elife. 2017 Jun 01;6:
pubmed: 28569666
Nat Commun. 2020 Oct 6;11(1):5016
pubmed: 33024106
Brain Commun. 2020 Mar 04;2(1):fcaa022
pubmed: 32954283
Elife. 2019 Oct 03;8:
pubmed: 31580259
Psychiatr Genet. 2011 Apr;21(2):90-7
pubmed: 21233784
Pflugers Arch. 2016 Mar;468(3):491-502
pubmed: 26687113
Hum Mutat. 2020 Nov;41(11):1892-1905
pubmed: 32741053
Nat Commun. 2020 Feb 21;11(1):998
pubmed: 32081874
Curr Opin Neurobiol. 1996 Jun;6(3):294-302
pubmed: 8794089
Nature. 1996 Oct 17;383(6601):634-7
pubmed: 8857541
Nature. 2004 Oct 14;431(7010):811-8
pubmed: 15483603
Eur J Neurosci. 1998 Mar;10(3):976-88
pubmed: 9753165
Cell. 2015 Jan 29;160(3):542-53
pubmed: 25635461
Biochemistry. 2010 May 4;49(17):3511-3
pubmed: 20349989
Nat Struct Mol Biol. 2013 Oct;20(10):1224-6
pubmed: 24013209
Chem Rev. 2016 Jun 8;116(11):6552-87
pubmed: 26892914
Biochemistry. 1982 Nov 23;21(24):6327-30
pubmed: 6129891
Biochemistry. 2017 Jun 6;56(22):2853-2859
pubmed: 28494585
J Neurosci. 1994 Sep;14(9):5559-69
pubmed: 7521911
Channels (Austin). 2011 Nov-Dec;5(6):468-74
pubmed: 21849820
EMBO J. 1997 Jul 1;16(13):3822-32
pubmed: 9233792
Neurochem Int. 2016 Sep;98:19-28
pubmed: 27129805
J Biol Chem. 2004 Sep 17;279(38):39505-12
pubmed: 15265858
Nature. 2015 Feb 5;518(7537):68-73
pubmed: 25652997
Biochemistry. 1990 Jul 17;29(28):6734-40
pubmed: 1697765
PLoS One. 2012;7(3):e33058
pubmed: 22427946
J Physiol. 2006 Nov 15;577(Pt 1):221-34
pubmed: 16973698
Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12486-91
pubmed: 23840066
Sci Adv. 2020 Nov 18;6(47):
pubmed: 33208356
J Biol Chem. 2003 Dec 12;278(50):50112-9
pubmed: 14506254
Nature. 1995 Jun 15;375(6532):599-603
pubmed: 7791878
J Neurosci. 2007 Mar 14;27(11):2943-7
pubmed: 17360917
Biophys J. 2011 Jun 8;100(11):2623-32
pubmed: 21641307
Nature. 1992 Dec 3;360(6403):464-7
pubmed: 1448170
Ann Neurol. 2019 Jun;85(6):921-926
pubmed: 30937933
J Biol Chem. 2015 Jun 26;290(26):15962-72
pubmed: 25922069
Brain. 2012 Nov;135(Pt 11):3416-25
pubmed: 23107647
J Clin Invest. 2011 Jan;121(1):446-53
pubmed: 21123949
Elife. 2018 Sep 26;7:
pubmed: 30255846
J Biol Chem. 2012 Aug 3;287(32):26921-31
pubmed: 22707712
Nat Struct Mol Biol. 2012 Feb 12;19(3):355-7
pubmed: 22343718
J Neurosci. 1998 Oct 1;18(19):7650-61
pubmed: 9742136
J Neurosci. 1998 Dec 1;18(23):9620-8
pubmed: 9822723
J Biol Chem. 2011 Feb 4;286(5):3935-43
pubmed: 21127051
Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9706-11
pubmed: 10931942
Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20752-7
pubmed: 19926849
J Biol Chem. 2014 Apr 18;289(16):11175-11182
pubmed: 24584931
Nat Commun. 2019 Jul 31;10(1):3427
pubmed: 31366933
J Biol Chem. 2009 Jun 26;284(26):17540-8
pubmed: 19380583
Biochemistry. 1996 May 14;35(19):6150-6
pubmed: 8634258
J Gen Physiol. 2016 Jul;148(1):13-24
pubmed: 27296367
Science. 1997 Jun 13;276(5319):1699-702
pubmed: 9180080
Nature. 2017 Apr 27;544(7651):446-451
pubmed: 28424515
Nature. 2007 Oct 11;449(7163):726-30
pubmed: 17704762
J Biol Chem. 2010 Jul 30;285(31):23676-86
pubmed: 20519505
J Neurosci. 2011 Apr 20;31(16):6255-62
pubmed: 21508248
J Biol Chem. 2014 Jan 17;289(3):1815-24
pubmed: 24307171
Prog Neurobiol. 2001 Sep;65(1):1-105
pubmed: 11369436
J Biol Chem. 2013 Dec 20;288(51):36492-501
pubmed: 24214974
J Neurosci. 1998 Sep 15;18(18):7099-110
pubmed: 9736633
Sci Rep. 2017 Oct 24;7(1):13913
pubmed: 29066757
J Physiol. 2006 Dec 1;577(Pt 2):591-9
pubmed: 17008380

Auteurs

Claudia Alleva (C)

Institute of Biological Information Processing, Molekular- und Zellphysiologie (IBI-1), Forschungszentrum Jülich, Jülich, Germany.

Jan-Philipp Machtens (JP)

Institute of Biological Information Processing, Molekular- und Zellphysiologie (IBI-1), Forschungszentrum Jülich, Jülich, Germany.
Institute of Clinical Pharmacology, RWTH Aachen University, Aachen, Germany.

Daniel Kortzak (D)

Institute of Biological Information Processing, Molekular- und Zellphysiologie (IBI-1), Forschungszentrum Jülich, Jülich, Germany.

Ingo Weyand (I)

Institute of Biological Information Processing, Molekular- und Zellphysiologie (IBI-1), Forschungszentrum Jülich, Jülich, Germany.

Christoph Fahlke (C)

Institute of Biological Information Processing, Molekular- und Zellphysiologie (IBI-1), Forschungszentrum Jülich, Jülich, Germany. c.fahlke@fz-juelich.de.
ORCID: 0000-0001-8602-9952

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Système X-AG de transport d'acides aminés › Molecular Basis of Coupled Transport and Anion...
questionsmedicales.fr › Eucaryotes › Animaux › Molecular Basis of Coupled Transport and Anion...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Anions › Molecular Basis of Coupled Transport and Anion...
questionsmedicales.fr › Métabolisme › Transport biologique › Molecular Basis of Coupled Transport and Anion...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Système X-AG de transport d'acides aminés › Protéines de transport transmembranaire du glutamate › Transporteur-1 d'acides aminés excitateurs › Molecular Basis of Coupled Transport and Anion...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Système X-AG de transport d'acides aminés › Protéines de transport transmembranaire du glutamate › Molecular Basis of Coupled Transport and Anion...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés excitateurs › Acide glutamique › Molecular Basis of Coupled Transport and Anion...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Molecular Basis of Coupled Transport and Anion...