High-Throughput Peptide Derivatization toward Supramolecular Diversification in Microtiter Plates.
Suzuki−Miyaura cross coupling
combinatorial synthesis
high-throughput screening
peptide
self-assembly
Journal
ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589
Informations de publication
Date de publication:
23 03 2021
23 03 2021
Historique:
pubmed:
16
2
2021
medline:
15
5
2021
entrez:
15
2
2021
Statut:
ppublish
Résumé
The evolution of life on earth eventually leads to the emergence of species with increased complexity and diversity. Similarly, evolutionary chemical space exploration in the laboratory is a key step to pursue the structural and functional diversity of supramolecular systems. Here, we present a powerful tool that enables rapid peptide diversification and employ it to expand the chemical space for supramolecular functions. Central to this strategy is the exploitation of palladium-catalyzed Suzuki-Miyaura cross-coupling reactions to direct combinatorial synthesis of peptide arrays in microtiter plates under an open atmosphere. Taking advantage of this
Identifiants
pubmed: 33587607
doi: 10.1021/acsnano.0c05423
pmc: PMC7992134
doi:
Substances chimiques
Hydrogels
0
Peptides
0
Palladium
5TWQ1V240M
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4034-4044Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R015651/1
Pays : United Kingdom
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