CTLA-4 blockade drives loss of T
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
01
11
2019
accepted:
03
02
2021
pubmed:
16
2
2021
medline:
8
1
2022
entrez:
15
2
2021
Statut:
ppublish
Résumé
Limiting metabolic competition in the tumour microenvironment may increase the effectiveness of immunotherapy. Owing to its crucial role in the glucose metabolism of activated T cells, CD28 signalling has been proposed as a metabolic biosensor of T cells
Identifiants
pubmed: 33588426
doi: 10.1038/s41586-021-03326-4
pii: 10.1038/s41586-021-03326-4
pmc: PMC8057670
mid: NIHMS1670113
doi:
Substances chimiques
CTLA-4 Antigen
0
CTLA4 protein, human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
652-658Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA215136
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA221810
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA082084
Pays : United States
Organisme : NIAID NIH HHS
ID : F31 AI149971
Pays : United States
Organisme : NIAID NIH HHS
ID : DP2 AI136598
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI135367
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
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