Trefoil Factor Family (TFF) Peptides and their Different Roles in the Mucosal Innate Immune Defense and More: An Update.
DMBT1
FCGBP
Innate immunity
SARS-CoV-2.
inflammation
lectin
mucin
trefoil factor
Journal
Current medicinal chemistry
ISSN: 1875-533X
Titre abrégé: Curr Med Chem
Pays: United Arab Emirates
ID NLM: 9440157
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
11
2020
revised:
08
01
2021
accepted:
20
01
2021
pubmed:
17
2
2021
medline:
26
11
2021
entrez:
16
2
2021
Statut:
ppublish
Résumé
Mucous epithelia are protected by complex mucus barrier layers, which are part of the innate immune defense. Trefoil factor family peptides TFF1, TFF2, and TFF3 have lectin activities and are predominantly co-secreted together with mucins from these epithelia. TFF1 and TFF2 are mainly expressed in the gastric mucosa, whereas TFF3 is widely secreted from most mucous epithelia and their glands. TFF1 and TFF3 consist of a single TFF domain and an additional free 7th cysteine residue, whereas TFF2 contains two TFF domains. Systematic analyses of the molecular forms of TFFs gave new insights into their diverse molecular functions. TFF1 mainly exists as a monomer with an unusual free thiol group and only minor amounts form a disulfide-linked homodimer as well as heterodimers with gastrokine-2 and IgG-Fc-binding protein (FCGBP). TFF3 mainly forms a heterodimer with FCGBP in vivo, but also binds Deleted in Malignant Brain Tumors/gp340 (DMBT1
Identifiants
pubmed: 33588719
pii: CMC-EPUB-114202
doi: 10.2174/0929867328666210215114140
doi:
Substances chimiques
Calcium-Binding Proteins
0
DMBT1 protein, human
0
DNA-Binding Proteins
0
Peptides
0
Trefoil Factor-1
0
Trefoil Factor-2
0
Trefoil Factors
0
Tumor Suppressor Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
7387-7399Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.