Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice.
Animals
Calbindin 1
/ genetics
Calcium-Binding Proteins
/ genetics
Co-Repressor Proteins
/ genetics
Core Binding Factor Alpha 2 Subunit
/ genetics
Core Binding Factor Alpha 3 Subunit
/ genetics
Feedback, Sensory
/ physiology
Ganglia, Spinal
/ cytology
Gene Expression
LIM Domain Proteins
/ genetics
Lectins, C-Type
/ genetics
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Motor Neurons
/ classification
Nerve Tissue Proteins
/ genetics
Physical Conditioning, Animal
Proprioception
/ physiology
Sensory Receptor Cells
/ classification
Single-Cell Analysis
Spinal Cord
/ cytology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
15 02 2021
15 02 2021
Historique:
received:
03
08
2020
accepted:
15
01
2021
entrez:
16
2
2021
pubmed:
17
2
2021
medline:
24
2
2021
Statut:
epublish
Résumé
Proprioceptive neurons (PNs) are essential for the proper execution of all our movements by providing muscle sensory feedback to the central motor network. Here, using deep single cell RNAseq of adult PNs coupled with virus and genetic tracings, we molecularly identify three main types of PNs (Ia, Ib and II) and find that they segregate into eight distinct subgroups. Our data unveil a highly sophisticated organization of PNs into discrete sensory input channels with distinct spatial distribution, innervation patterns and molecular profiles. Altogether, these features contribute to finely regulate proprioception during complex motor behavior. Moreover, while Ib- and II-PN subtypes are specified around birth, Ia-PN subtypes diversify later in life along with increased motor activity. We also show Ia-PNs plasticity following exercise training, suggesting Ia-PNs are important players in adaptive proprioceptive function in adult mice.
Identifiants
pubmed: 33589589
doi: 10.1038/s41467-021-21173-9
pii: 10.1038/s41467-021-21173-9
pmc: PMC7884389
doi:
Substances chimiques
Calb1 protein, mouse
0
Calbindin 1
0
Calcium-Binding Proteins
0
Co-Repressor Proteins
0
Core Binding Factor Alpha 2 Subunit
0
Core Binding Factor Alpha 3 Subunit
0
Doc2b protein, mouse
0
LIM Domain Proteins
0
Lectins, C-Type
0
Lmcd1 protein, mouse
0
Nerve Tissue Proteins
0
Runx1 protein, mouse
0
Runx3 protein, mouse
0
chondrolectin, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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