Reactive astrocyte nomenclature, definitions, and future directions.

Aging / pathology Animals Astrocytes / pathology Brain / pathology Brain Diseases / pathology Brain Injuries / pathology Humans Spinal Cord / pathology Spinal Cord Injuries / pathology

Journal

Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671

Informations de publication

Date de publication:
03 2021
Historique:
received: 13 08 2020
accepted: 16 12 2020
pubmed: 17 2 2021
medline: 30 3 2021
entrez: 16 2 2021
Statut: ppublish

Résumé

Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters-preferably in vivo-plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions.

Identifiants

DOI: 10.1038/s41593-020-00783-4 PMID: 33589835 PMC: PMC8007081
pubmed: 33589835
doi: 10.1038/s41593-020-00783-4
pii: 10.1038/s41593-020-00783-4
pmc: PMC8007081
mid: NIHMS1675128
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

312-325

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS102807
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110690
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG027297
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG066171
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG060974
Pays : United States
Organisme : Intramural CDC HHS
ID : CC999999
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG061774
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056998
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS084030
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_17230
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : K08 AG064039
Pays : United States
Organisme : Medical Research Council
ID : MR/P008658/1
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH104701
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA048822
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM123971
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS105807
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS036692
Pays : United States

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Auteurs

Carole Escartin (C)

Université Paris-Saclay, CEA, CNRS, MIRCen, Laboratoire des Maladies Neurodégénératives, Fontenay-aux-Roses, France. carole.escartin@cea.fr.
ORCID: 0000-0003-3613-4118

Elena Galea (E)

Institut de Neurociències and Departament de Bioquímica i Biologia Molecular, Unitat de Bioquímica de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain. Elena.Galea@uab.es.
ICREA, Barcelona, Spain. Elena.Galea@uab.es.
ORCID: 0000-0003-4537-9897

András Lakatos (A)

John van Geest Centre for Brain Repair and Division of Stem Cell Neurobiology, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Wellcome Trust-MRC Cambridge Stem Cell Institute, Cambridge Biomedical Campus, Cambridge, UK.
ORCID: 0000-0002-1301-2292

James P O'Callaghan (JP)

Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.

Gabor C Petzold (GC)

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Division of Vascular Neurology, Department of Neurology, University Hospital Bonn, Bonn, Germany.
ORCID: 0000-0002-0145-8641

Alberto Serrano-Pozo (A)

Alzheimer Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Harvard Medical School, Boston, Massachusetts, USA.
ORCID: 0000-0003-0899-7530

Christian Steinhäuser (C)

Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Bonn, Germany.

Andrea Volterra (A)

Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.
ORCID: 0000-0003-1069-1602

Giorgio Carmignoto (G)

Neuroscience Institute, Italian National Research Council (CNR), Padua, Italy.
Department of Biomedical Sciences, University of Padua, Padua, Italy.

Amit Agarwal (A)

The Chica and Heinz Schaller Research Group, Institute for Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany.

Nicola J Allen (NJ)

Salk Institute for Biological Studies, Molecular Neurobiology Laboratory, La Jolla, California, USA.

Alfonso Araque (A)

Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA.
ORCID: 0000-0003-3840-1144

Luis Barbeito (L)

Institut Pasteur de Montevideo, Montevideo, Uruguay.
ORCID: 0000-0002-3047-232X

Ari Barzilai (A)

Department of Neurobiology, George S. Wise, Faculty of Life Sciences and Sagol School of Neuroscience, Tel Aviv University, Ramat Aviv Tel Aviv, Israel.

Dwight E Bergles (DE)

The Solomon H. Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Gilles Bonvento (G)

Université Paris-Saclay, CEA, CNRS, MIRCen, Laboratoire des Maladies Neurodégénératives, Fontenay-aux-Roses, France.
ORCID: 0000-0002-2886-4228

Arthur M Butt (AM)

School of Pharmacy and Biomedical Science, University of Portsmouth, Portsmouth, UK.
ORCID: 0000-0001-7579-0746

Wei-Ting Chen (WT)

Center for Brain and Disease Research, VIB and University of Leuven, Leuven, Belgium.

Martine Cohen-Salmon (M)

'Physiology and Physiopathology of the Gliovascular Unit' Research Group, Center for Interdisciplinary Research in Biology (CIRB), College de France, Unité Mixte de Recherche 7241 CNRS, Unité1050 INSERM, PSL Research University, Paris, France.

Colm Cunningham (C)

Trinity Biomedical Sciences Institute & Trinity College Institute of Neuroscience, School of Biochemistry & Immunology, Trinity College Dublin, Dublin, Republic of Ireland.

Benjamin Deneen (B)

Center for Cell and Gene Therapy, Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA.
ORCID: 0000-0002-6335-1081

Bart De Strooper (B)

Center for Brain and Disease Research, VIB and University of Leuven, Leuven, Belgium.
UK Dementia Research Institute at the University College London, London, UK.

Blanca Díaz-Castro (B)

UK Dementia Research Institute at the University of Edinburgh, Centre for Discovery Brain Sciences, Edinburgh, UK.

Cinthia Farina (C)

Institute of Experimental Neurology (INSpe) and Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
ORCID: 0000-0002-4466-9676

Marc Freeman (M)

Vollum Institute, OHSU, Portland, Oregon, USA.

Vittorio Gallo (V)

Center for Neuroscience Research, Children's National Research Institute, Children's National Hospital, Washington DC, USA.
ORCID: 0000-0002-2429-0845

James E Goldman (JE)

Department of Pathology & Cell Biology, Columbia University, New York, New York, USA.

Steven A Goldman (SA)

University of Rochester Medical Center, Rochester, New York, USA.
Center for Translational Neuromedicine, University of Copenhagen Faculty of Health and Medical Science and Rigshospitalet, Kobenhavn N, Denmark.
ORCID: 0000-0002-5498-4303

Magdalena Götz (M)

Physiological Genomics, Biomedical Center, Ludwig-Maximilians-Universitaet & Institute of Stem Cell Research, Helmholtz Center Munich, Munich, Germany.
Synergy, Excellence Cluster of Systems Neurology, Biomedical Center, Munich, Germany.
ORCID: 0000-0003-1551-9203

Antonia Gutiérrez (A)

Dpto. Biología Celular, Genética y Fisiología, Instituto de Investigación Biomédica de Málaga-IBIMA, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain.
Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
ORCID: 0000-0002-6264-6152

Philip G Haydon (PG)

Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
ORCID: 0000-0001-5698-6698

Dieter H Heiland (DH)

Microenvironment and Immunology Research Laboratory, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Department of Neurosurgery, Medical Center, University of Freiburg, Faculty of Medicine, Freiburg, Germany.
ORCID: 0000-0002-9258-3033

Elly M Hol (EM)

Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
ORCID: 0000-0001-5604-2603

Matthew G Holt (MG)

Laboratory of Glia Biology, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.
ORCID: 0000-0002-8958-4027

Masamitsu Iino (M)

Division of Cellular and Molecular Pharmacology, Nihon University School of Medicine, Tokyo, Japan.

Ksenia V Kastanenka (KV)

Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.

Helmut Kettenmann (H)

Cellular Neurosciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.

Baljit S Khakh (BS)

Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

Schuichi Koizumi (S)

Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan.
ORCID: 0000-0001-6184-3106

C Justin Lee (CJ)

Center for Cognition and Sociality, Institute for Basic Science 55, Expo-ro, Yuseong-gu, Daejeon, Korea.

Shane A Liddelow (SA)

Neuroscience Institute, Department of Neuroscience and Physiology, Department of Ophthalmology, NYU School of Medicine, New York, USA.

Brian A MacVicar (BA)

Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.
ORCID: 0000-0003-4596-4623

Pierre Magistretti (P)

Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Centre de Neurosciences Psychiatriques, University of Lausanne and CHUV, Site de Cery, Prilly-Lausanne, Lausanne, Switzerland.

Albee Messing (A)

Waisman Center and School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Anusha Mishra (A)

Department of Neurology Jungers Center for Neurosciences Research and Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
ORCID: 0000-0002-3642-5049

Anna V Molofsky (AV)

Departments of Psychiatry/Weill Institute for Neuroscience University of California, San Francisco, California, USA.
ORCID: 0000-0002-4709-2411

Keith K Murai (KK)

Centre for Research in Neuroscience, Department of Neurology & Neurosurgery, Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.

Christopher M Norris (CM)

Sanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, Kentucky, USA.

Seiji Okada (S)

Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
ORCID: 0000-0002-5107-8209

Stéphane H R Oliet (SHR)

Université de Bordeaux, Inserm, Neurocentre Magendie, U1215, Bordeaux, France.

João F Oliveira (JF)

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
ICVS/3B's -PT Government Associate Laboratory, Braga/Guimarães, Portugal.
IPCA-EST-2Ai, Polytechnic Institute of Cávado and Ave, Applied Artificial Intelligence Laboratory, Campus of IPCA, Barcelos, Portugal.
ORCID: 0000-0002-1005-2328

Aude Panatier (A)

Université de Bordeaux, Inserm, Neurocentre Magendie, U1215, Bordeaux, France.
ORCID: 0000-0002-6107-4463

Vladimir Parpura (V)

Department of Neurobiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.

Marcela Pekna (M)

Laboratory of Regenerative Neuroimmunology, Center for Brain Repair, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
ORCID: 0000-0003-2734-8237

Milos Pekny (M)

Laboratory of Astrocyte Biology and CNS Regeneration, Center for Brain Repair, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Luc Pellerin (L)

INSERM U1082, Université de Poitiers, Poitiers, France.

Gertrudis Perea (G)

Department of Functional and Systems Neurobiology, Cajal Institute, CSIC, Madrid, Spain.
ORCID: 0000-0001-5924-9175

Beatriz G Pérez-Nievas (BG)

Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Frank W Pfrieger (FW)

Centre National de la Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.
ORCID: 0000-0001-7085-1431

Kira E Poskanzer (KE)

Department of Biochemistry & Biophysics, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, California, USA.
ORCID: 0000-0003-4830-8891

Francisco J Quintana (FJ)

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School. Associate Member, The Broad Institute, Boston, Massachusetts, USA.

Richard M Ransohoff (RM)

Third Rock Ventures, Boston, Massachusetts, USA.

Miriam Riquelme-Perez (M)

Université Paris-Saclay, CEA, CNRS, MIRCen, Laboratoire des Maladies Neurodégénératives, Fontenay-aux-Roses, France.

Stefanie Robel (S)

Fralin Biomedical Research Institute at Virginia Tech Carilion, School of Neuroscience Virginia Tech, Riverside Circle, Roanoke, Virginia, USA.

Christine R Rose (CR)

Institute of Neurobiology, Heinrich Heine University, Düsseldorf, Germany.
ORCID: 0000-0002-9684-3592

Jeffrey D Rothstein (JD)

Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
ORCID: 0000-0003-2001-8470

Nathalie Rouach (N)

Neuroglial Interactions in Cerebral Physiology and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, CNRS UMR 7241, INSERM U1050, Labex Memolife, PSL Research University Paris, Paris, France.
ORCID: 0000-0002-5574-888X

David H Rowitch (DH)

Wellcome Trust-MRC Cambridge Stem Cell Institute, Cambridge Biomedical Campus, Cambridge, UK.
ORCID: 0000-0002-0079-0060

Alexey Semyanov (A)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
Sechenov First Moscow State Medical University, Moscow, Russia.
ORCID: 0000-0002-6800-0942

Swetlana Sirko (S)

Physiological Genomics, Biomedical Center, LMU Munich, Munich, Germany.
Institute for Stem Cell Research, Helmholtz Zentrum Munich, Neuherberg, Germany.
ORCID: 0000-0001-5950-616X

Harald Sontheimer (H)

Virginia Tech School of Neuroscience and Center for Glial Biology in Health, Disease and Cancer, Virginia Tech at the Fralin Biomedical Research Institute, Roanoke, Virginia, USA.
ORCID: 0000-0002-5843-9871

Raymond A Swanson (RA)

Dept. of Neurology, University of California San Francisco and San Francisco Veterans Affairs Health Care System, San Francisco, California, USA.
ORCID: 0000-0002-3664-5359

Javier Vitorica (J)

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Dept. Bioquímica y Biología Molecular, Instituto de Biomedicina de Sevilla, Universidad de Sevilla, Hospital Virgen del Rocío/CSIC, Sevilla, Spain.

Ina-Beate Wanner (IB)

Semel Institute for Neuroscience & Human Behavior, IDDRC, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.

Levi B Wood (LB)

George W. Woodruff School of Mechanical Engineering, Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory, and Parker H. Petit Institute for Bioengineering & Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA.

Jiaqian Wu (J)

The Vivian L. Smith Department of Neurosurgery, Center for Stem Cell and Regenerative Medicine, MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, McGovern Medical School, UTHealth, University of Texas Health Science Center at Houston, Houston, TX, USA.

Binhai Zheng (B)

Department of Neurosciences, UC San Diego School of Medicine, La Jolla; VA San Diego Research Service, San Diego, CA, USA.

Eduardo R Zimmer (ER)

Department of Pharmacology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Robert Zorec (R)

Laboratory of Neuroendocrinology, Molecular Cell Physiology, Institute of Pathophysiology, University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia.
Celica Biomedical, 1000, Ljubljana, Slovenia.
ORCID: 0000-0002-7478-3875

Michael V Sofroniew (MV)

Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, California, USA. sofroniew@mednet.ucla.edu.
ORCID: 0000-0001-6075-0178

Alexei Verkhratsky (A)

Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. alexej.verkhratsky@manchester.ac.uk.
Achúcarro Basque Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain. alexej.verkhratsky@manchester.ac.uk.
ORCID: 0000-0003-2592-9898

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Reactive astrocyte nomenclature, definitions,...
questionsmedicales.fr › Eucaryotes › Animaux › Reactive astrocyte nomenclature, definitions,...
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Reactive astrocyte nomenclature, definitions,...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Reactive astrocyte nomenclature, definitions,...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Reactive astrocyte nomenclature, definitions,...
questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Traumatismes cranioencéphaliques › Lésions encéphaliques › Reactive astrocyte nomenclature, definitions,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Reactive astrocyte nomenclature, definitions,...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Reactive astrocyte nomenclature, definitions,...
questionsmedicales.fr › Plaies et blessures › Traumatismes de la moelle épinière › Reactive astrocyte nomenclature, definitions,...