Knee osteoarthritis and time-to all-cause mortality in six community-based cohorts: an international meta-analysis of individual participant-level data.


Journal

Aging clinical and experimental research
ISSN: 1720-8319
Titre abrégé: Aging Clin Exp Res
Pays: Germany
ID NLM: 101132995

Informations de publication

Date de publication:
Mar 2021
Historique:
received: 02 11 2020
accepted: 21 11 2020
pubmed: 17 2 2021
medline: 12 3 2021
entrez: 16 2 2021
Statut: ppublish

Résumé

Osteoarthritis (OA) is a chronic joint disease, with increasing global burden of disability and healthcare utilisation. Recent meta-analyses have shown a range of effects of OA on mortality, reflecting different OA definitions and study methods. We seek to overcome limitations introduced when using aggregate results by gathering individual participant-level data (IPD) from international observational studies and standardising methods to determine the association of knee OA with mortality in the general population. Seven community-based cohorts were identified containing knee OA-related pain, radiographs, and time-to-mortality, six of which were available for analysis. A two-stage IPD meta-analysis framework was applied: (1) Cox proportional hazard models assessed time-to-mortality of participants with radiographic OA (ROA), OA-related pain (POA), and a combination of pain and ROA (PROA) against pain and ROA-free participants; (2) hazard ratios (HR) were then pooled using the Hartung-Knapp modification for random-effects meta-analysis. 10,723 participants in six cohorts from four countries were included in the analyses. Multivariable models (adjusting for age, sex, race, BMI, smoking, alcohol consumption, cardiovascular disease, and diabetes) showed a pooled HR, compared to pain and ROA-free participants, of 1.03 (0.83, 1.28) for ROA, 1.35 (1.12, 1.63) for POA, and 1.37 (1.22, 1.54) for PROA. Participants with POA or PROA had a 35-37% increased association with reduced time-to-mortality, independent of confounders. ROA showed no association with mortality, suggesting that OA-related knee pain may be driving the association with time-to-mortality. Versus Arthritis Centre for Sport, Exercise and Osteoarthritis and Osteoarthritis Research Society International.

Sections du résumé

BACKGROUND BACKGROUND
Osteoarthritis (OA) is a chronic joint disease, with increasing global burden of disability and healthcare utilisation. Recent meta-analyses have shown a range of effects of OA on mortality, reflecting different OA definitions and study methods. We seek to overcome limitations introduced when using aggregate results by gathering individual participant-level data (IPD) from international observational studies and standardising methods to determine the association of knee OA with mortality in the general population.
METHODS METHODS
Seven community-based cohorts were identified containing knee OA-related pain, radiographs, and time-to-mortality, six of which were available for analysis. A two-stage IPD meta-analysis framework was applied: (1) Cox proportional hazard models assessed time-to-mortality of participants with radiographic OA (ROA), OA-related pain (POA), and a combination of pain and ROA (PROA) against pain and ROA-free participants; (2) hazard ratios (HR) were then pooled using the Hartung-Knapp modification for random-effects meta-analysis.
FINDINGS RESULTS
10,723 participants in six cohorts from four countries were included in the analyses. Multivariable models (adjusting for age, sex, race, BMI, smoking, alcohol consumption, cardiovascular disease, and diabetes) showed a pooled HR, compared to pain and ROA-free participants, of 1.03 (0.83, 1.28) for ROA, 1.35 (1.12, 1.63) for POA, and 1.37 (1.22, 1.54) for PROA.
DISCUSSION CONCLUSIONS
Participants with POA or PROA had a 35-37% increased association with reduced time-to-mortality, independent of confounders. ROA showed no association with mortality, suggesting that OA-related knee pain may be driving the association with time-to-mortality.
FUNDING BACKGROUND
Versus Arthritis Centre for Sport, Exercise and Osteoarthritis and Osteoarthritis Research Society International.

Identifiants

pubmed: 33590469
doi: 10.1007/s40520-020-01762-2
pii: 10.1007/s40520-020-01762-2
pmc: PMC7943431
doi:

Types de publication

Journal Article Meta-Analysis

Langues

eng

Sous-ensembles de citation

IM

Pagination

529-545

Subventions

Organisme : Versus Arthritis
ID : 21595
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12011/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_A620_1014
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 17702
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0400491
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U147585819
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_21000
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U147585827
Pays : United Kingdom
Organisme : NIAMS NIH HHS
ID : P30 AR072571
Pays : United States
Organisme : Medical Research Council
ID : MC_U147585824
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_21001
Pays : United Kingdom

Investigateurs

Lyn March (L)
Gillian Hawker (G)
Philip Conaghan (P)
Virginia Byers Kraus (VB)
Ali Guermazi (A)
David Hunter (D)
Jeffrey N Katz (JN)
Tim McAlindon (T)
Tuhina Neogi (T)
Lee Simon (L)
Marita Cross (M)
Lauren King (L)

Références

Am J Epidemiol. 1988 Jul;128(1):179-89
pubmed: 3381825
RMD Open. 2019 Nov 13;5(2):e001048
pubmed: 31798954
Osteoarthritis Cartilage. 2018 Jul;26(7):872-879
pubmed: 29426005
Stat Methods Med Res. 2007 Jun;16(3):219-42
pubmed: 17621469
Ann Rheum Dis. 1957 Dec;16(4):494-502
pubmed: 13498604
Ann Rheum Dis. 2004 Apr;63(4):408-14
pubmed: 15020335
Arthritis Care Res (Hoboken). 2018 Feb;70(2):236-243
pubmed: 28589671
Clin Exp Rheumatol. 2008 Sep-Oct;26(5 Suppl 51):S120-4
pubmed: 19026154
Osteoarthritis Cartilage. 2007;15 Suppl A:A1-56
pubmed: 17320422
Osteoarthritis Cartilage. 2019 Apr;27(4):593-602
pubmed: 30583096
Arthritis Care Res. 1995 Dec;8(4):242-50
pubmed: 8605262
BMJ. 2001 Jul 28;323(7306):224-8
pubmed: 11473921
Ann Rheum Dis. 2008 Sep;67(9):1256-61
pubmed: 18174218
Ann Rheum Dis. 1994 Mar;53(3):158-62
pubmed: 8154931
Br Med Bull. 2013;105:185-99
pubmed: 23337796
Rheumatology (Oxford). 2014 Feb;53(2):293-9
pubmed: 24158755
J Rheumatol. 1988 Dec;15(12):1833-40
pubmed: 3068365
Prev Med. 1975 Dec;4(4):518-25
pubmed: 1208363
Ann Rheum Dis. 2016 Oct;75(10):1749-56
pubmed: 26543059
Epidemiology. 2016 Jul;27(4):479-85
pubmed: 26986874
Arthritis Rheum. 1987 Aug;30(8):914-8
pubmed: 3632732
Semin Arthritis Rheum. 2016 Oct;46(2):160-167
pubmed: 27179749
Sci Rep. 2016 Apr 18;6:24393
pubmed: 27087682
J Community Health. 1990 Jun;15(3):195-208
pubmed: 2365841
Arthritis Rheum. 2008 Sep 15;59(9):1207-13
pubmed: 18759314
Stat Med. 2009 Jul 10;28(15):1982-98
pubmed: 19452569
Osteoarthritis Cartilage. 2020 Oct;28(10):1330-1340
pubmed: 32777267
BMJ. 2011 Mar 08;342:d1165
pubmed: 21385807
Lancet. 2018 Nov 10;392(10159):1789-1858
pubmed: 30496104
Osteoarthritis Cartilage. 2011 Nov;19(11):1270-85
pubmed: 21907813
Sci Rep. 2017 Jun 12;7(1):3309
pubmed: 28607349
Aging Clin Exp Res. 2019 Aug;31(8):1049-1056
pubmed: 30903599
Osteoarthritis Cartilage. 2015 Jul;23(7):1154-7
pubmed: 25819581
BMC Med Res Methodol. 2014 Feb 18;14:25
pubmed: 24548571
BMC Med Res Methodol. 2014 Jun 19;14:79
pubmed: 24943877
Stat Med. 2017 Feb 28;36(5):855-875
pubmed: 27747915
Ann Rheum Dis. 2008 Jul;67(7):1034-6
pubmed: 18198197
Arthritis Rheum. 2009 May 15;61(5):641-7
pubmed: 19405001
J Clin Epidemiol. 2007 May;60(5):431-9
pubmed: 17419953
Epidemiology. 2016 Jul;27(4):477-8
pubmed: 26986873
Stat Med. 2001 Dec 30;20(24):3875-89
pubmed: 11782040
BMC Musculoskelet Disord. 2008 Jun 26;9:95
pubmed: 18582362
PLoS One. 2014 Mar 07;9(3):e91286
pubmed: 24608134
BMJ. 2010 Feb 05;340:c221
pubmed: 20139215
Ann Intern Med. 2011 Feb 15;154(4):217-26
pubmed: 21320937
J Bone Miner Metab. 2011 Mar;29(2):217-23
pubmed: 20711854
BMJ. 2001 Jul 14;323(7304):101-5
pubmed: 11451790
Rheumatology (Oxford). 2000 Sep;39(9):955-61
pubmed: 10986299

Auteurs

Kirsten M Leyland (KM)

MRC Integrated Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK.
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Lucy S Gates (LS)

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, University of Southampton, Southampton, UK.

Maria T Sanchez-Santos (MT)

Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Michael C Nevitt (MC)

Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.

David Felson (D)

Boston University School of Medicine, Boston, MA, USA.

Graeme Jones (G)

Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.

Joanne M Jordan (JM)

Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

Andrew Judge (A)

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Dani Prieto-Alhambra (D)

Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Noriko Yoshimura (N)

Department of Preventive Medicine for Locomotive Organ Disorders, 22nd Century Medical and Research Center, The University of Tokyo, Tokyo, Japan.

Julia L Newton (JL)

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Leigh F Callahan (LF)

Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

Cyrus Cooper (C)

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.

Mark E Batt (ME)

Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, Nottingham University Hospitals, Nottingham, UK.

Jianhao Lin (J)

Peking University People's Hospital, Arthritis Clinic and Research Centre, Beijing, China.

Qiang Liu (Q)

Peking University People's Hospital, Arthritis Clinic and Research Centre, Beijing, China.

Rebecca J Cleveland (RJ)

Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

Gary S Collins (GS)

Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Nigel K Arden (NK)

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. nigel.arden@ndorms.ox.ac.uk.
MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK. nigel.arden@ndorms.ox.ac.uk.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH