CC Chemokine Receptor 5 Targeted Nanoparticles Imaging the Progression and Regression of Atherosclerosis Using Positron Emission Tomography/Computed Tomography.
Alanine
/ metabolism
Animals
Apolipoproteins E
/ metabolism
Atherosclerosis
/ diagnostic imaging
Chemokines
/ metabolism
Copper Radioisotopes
/ metabolism
Disease Models, Animal
Humans
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Nanoparticles
/ administration & dosage
Plaque, Atherosclerotic
/ diagnostic imaging
Positron Emission Tomography Computed Tomography
/ methods
Radiopharmaceuticals
/ metabolism
Receptors, CCR5
/ metabolism
CCR5
atherosclerosis
macrophage
nanoparticle
positron emission tomography
Journal
Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791
Informations de publication
Date de publication:
01 03 2021
01 03 2021
Historique:
pubmed:
17
2
2021
medline:
3
11
2021
entrez:
16
2
2021
Statut:
ppublish
Résumé
Chemokines and chemokine receptors play an important role in the initiation and progression of atherosclerosis by mediating the trafficking of inflammatory cells. Chemokine receptor 5 (CCR5) has major implications in promoting the development of plaques to advanced stage and related vulnerability. CCR5 antagonist has demonstrated the effective inhibition of atherosclerotic progression in mice, making it a potential biomarker for atherosclerosis management. To accurately determine CCR5
Identifiants
pubmed: 33591187
doi: 10.1021/acs.molpharmaceut.0c01183
pmc: PMC8737066
mid: NIHMS1766138
doi:
Substances chimiques
Apolipoproteins E
0
CCR5 protein, mouse
0
Chemokines
0
Copper Radioisotopes
0
D-Ala-peptide T-amide
0
Radiopharmaceuticals
0
Receptors, CCR5
0
Alanine
OF5P57N2ZX
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1386-1396Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK056341
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL138163
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL125655
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL145212
Pays : United States
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