Autism Detection in Children by Combined Use of Gaze Preference and the M-CHAT-R in a Resource-Scarce Setting.
ASD diagnosis
Autism spectrum disorder
Developmental disorder
Eye tracking
Gaze preference
Journal
Journal of autism and developmental disorders
ISSN: 1573-3432
Titre abrégé: J Autism Dev Disord
Pays: United States
ID NLM: 7904301
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
accepted:
07
01
2021
pubmed:
17
2
2021
medline:
12
5
2021
entrez:
16
2
2021
Statut:
ppublish
Résumé
Most children with autism spectrum disorder (ASD), in resource-limited settings (RLS), are diagnosed after the age of four. Our work confirmed and extended results of Pierce that eye tracking could discriminate between typically developing (TD) children and those with ASD. We demonstrated the initial 15 s was at least as discriminating as the entire video. We evaluated the GP-MCHAT-R, which combines the first 15 s of manually-coded gaze preference (GP) video with M-CHAT-R results on 73 TD children and 28 children with ASD, 36-99 months of age. The GP-MCHAT-R (AUC = 0.89 (95%CI: 0.82-0.95)), performed significantly better than the MCHAT-R (AUC = 0.78 (95%CI: 0.71-0.85)) and gaze preference (AUC = 0.76 (95%CI: 0.64-0.88)) alone. This tool may enable early screening for ASD in RLS.
Identifiants
pubmed: 33591436
doi: 10.1007/s10803-021-04878-0
pii: 10.1007/s10803-021-04878-0
pmc: PMC7954728
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
994-1006Subventions
Organisme : Innóvate Perú
ID : Contrato N 153 PNICP-PIAP-2015
Organisme : Wendy Klag grant through Johns Hopkins University
ID : 160502174
Organisme : Bill and Melinda Gates Foundation
ID : OPPOPP1140557
Investigateurs
Vanessa Cavallera
(V)
Ricardo Zavaleta
(R)
Juan Flores
(J)
Dennis Nuñez
(D)
Alejandro Dioses
(A)
Anna Smith
(A)
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