HIV transmission network analysis allows identifying unreported risk factors in HIV-positive blood donors in France.
Adult
Blood Donors
/ statistics & numerical data
Blood Transfusion
/ legislation & jurisprudence
Case-Control Studies
Donor Selection
/ legislation & jurisprudence
Female
France
/ epidemiology
HIV Infections
/ transmission
HIV Seropositivity
/ epidemiology
Homosexuality, Male
/ statistics & numerical data
Humans
Male
Middle Aged
Risk Factors
Social Network Analysis
HIV infection
blood donor deferral
public health
risk factors
transmission network
Journal
Transfusion
ISSN: 1537-2995
Titre abrégé: Transfusion
Pays: United States
ID NLM: 0417360
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
revised:
04
12
2020
received:
02
07
2020
accepted:
05
12
2020
pubmed:
17
2
2021
medline:
2
7
2021
entrez:
16
2
2021
Statut:
ppublish
Résumé
As sex between men is a major route of human immunodeficiency virus (HIV) infection in most western countries, restrictive deferral rules for blood donation have largely been implemented regarding men having sex with men (MSM). Here, we sought here to assign unreported HIV risk factors in blood donors (BDs) and reevaluated the MSM-associated fraction of HIV transfusion residual risk (%RR We applied a genetic distance-based approach to infer an HIV transmission network for 384 HIV sequences from French BDs and 1337 HIV sequences from individuals with known risk factors (ANRS PRIMO primary HIV infection cohort). We validated the possibility of assigning a risk factor according to clustering using assortative mixing. Finally, we recalculated the %RR A total of 81 of 284 (28.5%) male and 5 of 100 (5%) female BDs belonged to a cluster; 72 (88.9%) of the 81 male BDs belonged to MSM clusters. After cluster correction, 8 of 67 (11.9%), 4 of 21 (19.0%), and 19 of 88 (21.6%) HIV-positive (HIV+) male BDs with heterosexual, other, or unknown risk factors could be reclassified as MSM, accounting for 10.9% of the total HIV+ male BDs. Overall, 139 of 284 HIV+ male donors (48.9%) could be considered MSM between 2000 and 2016 in France. Between 2005 and 2016, the %RR Network inference can be used to complement declaration data on risk factors for HIV infection in BDs. This approach, complementary to behavioral studies, is a valuable tool to evaluate the effect of changes in deferral criteria on BD compliance.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1191-1201Informations de copyright
© 2021 AABB.
Références
Cappy P, Barlet V, Lucas Q, Tinard X, Pillonel J, Gross S, et al. Transfusion of HIV-infected blood products despite highly sensitive nucleic acid testing. Transfusion. 2019;59:2046-53.
Wong HTH, Lee SS, Lee C-K, Chan DPC. Failure of self-disclosure of deferrable risk behaviors associated with transfusion-transmissible infections in blood donors. Transfusion. 2015;55:2175-83.
OʼBrien SF, Xi G, Yi Q-L, Goldman M. Understanding non-disclosure of deferrable risk: a study of blood donors with a history of intravenous drug use. Transfus Med. 2010;20:15-21.
Lucky TTA, Seed CR, Waller D, Lee JF, McDonald A, Wand H, et al. Understanding noncompliance with selective donor deferral criteria for high-risk behaviors in Australian blood donors. Transfusion. 2014;54:1739-49.
Duquesnoy A, Danic B, Santos A, Martinaud C, Woimant G, Laperche S, et al. Context and social perceptions of blood donation in donors found positive for human immunodeficiency virus in France. Transfusion. 2017;57:2240-7.
Lucky TTA, Seed CR, Keller A, Lee J, McDonald A, Ismay S, et al. Trends in transfusion-transmissible infections among Australian blood donors from 2005 to 2010. Transfusion. 2013;53:2751-62.
Slot E, Janssen MP, Marijt-van der Kreek T, Zaaijer HL, Van de Laar TJ. Two decades of risk factors and transfusion-transmissible infections in Dutch blood donors. Transfusion. 2016;56:203-14.
Custer B, Kessler D, Vahidnia F, Leparc G, Krysztof DE, Shaz B, et al. Risk factors for retrovirus and hepatitis virus infections in accepted blood donors. Transfusion. 2015;55:1098-107.
Tiberghien P, Pillonel J, Toujas F, Vallet B. Changes in Franceʼs deferral of blood donation by men who have sex with men. N Engl J Med. 2017;376:1485-6.
Goldman M, W-Y Shih A, OʼBrien SF, Devine D. Donor deferral policies for men who have sex with men: past, present and future. Vox Sang. 2018;113:95-103.
Sauvage C, Charpentier F, Guarrabe E, Pelat C, Spinardi R, Danic B, et al. Noncompliance to blood donor selection criteria by menwho have sex with men - Complidon 2017, France. Vox Sang. 2020;115:628-36. https://doi.org/10.1111/vox.12975.
Little SJ, Kosakovsky Pond SL, Anderson CM, Young JA, Wertheim JO, Mehta SR, et al. Using HIV networks to inform real time prevention interventions. PLoS One. 2014;9:e98443.
Poon AFY, Joy JB, Woods CK, Shurgold S, Colley G, Brumme CJ, et al. The impact of clinical, demographic and risk factors on rates of HIV transmission: a population-based phylogenetic analysis in British Columbia, Canada. J Infect Dis. 2015;211:926-35.
Brand D, Capsec J, Chaillon A, Cazein F, le Vu S, Moreau A, et al. HIV surveillance combining an assay for identification of very recent infection and phylogenetic analyses on dried spots. AIDS. 2017;31:407-16.
Chaillon A, Essat A, Frange P, Smith DM, Delaugerre C, Barin F, et al. Spatiotemporal dynamics of HIV-1 transmission in France (1999-2014) and impact of targeted prevention strategies. Retrovirology. 2017;14:15.
Oster AM, France AM, Panneer N, Bañez Ocfemia MC, Campbell E, Dasgupta S, et al. Identifying clusters of recent and rapid HIV transmission through analysis of molecular surveillance data. J Acquir Immune Defic Syndr. 2018;79:543-50.
Volz EM, Le Vu S, Ratmann O, Tostevin A, Dunn D, Orkin C, et al. Molecular epidemiology of HIV-1 subtype B reveals heterogeneous transmission risk: implications for intervention and control. J Infect Dis. 2018;217:1522-9.
Frange P, Meyer L, Deveau C, Tran L, Goujard C, Ghosn J, et al. Recent HIV-1 infection contributes to the viral diffusion over the French territory with a recent increasing frequency. PLoS One. 2012;7:e31695.
Wertheim JO, Kosakovsky Pond SL, Forgione LA, Mehta SR, Murrell B, Shah S, et al. Social and genetic networks of HIV-1 transmission in New York City. PLoS Pathog. 2017;13:e1006000.
Newman M. Mixing patterns in networks. Phys Rev E Stat Nonlin Soft Matter Phys. 2003;67(2, pt 2):026126.
French National Agency for research on HIV and viral hepatitis. HIV drug-resistance testing. Available from: http://www.hivfrenchresistance.org/ANRS-procedures.pdf. [cited 2020 June].
Barin F, Meyer L, Lancar R, Deveau C, Gharib M, Laporte A, et al. Development and validation of an immunoassay for identification of recent human immunodeficiency virus type 1 infections and its use on dried serum spots. J Clin Microbiol. 2005;43:4441-7.
Goujard C, Bonarek M, Meyer L, Bonnet F, Chaix ML, Deveau C, et al. CD4 cell count and HIV DNA level are independent predictors of disease progression after primary HIV type 1 infection in untreated patients. Clin Infect Dis. 2006;42:709-15.
Novelli S, Lécuroux C, Avettand-Fenoël V, Seng R, Essat A, Morlat P, et al. Long-term therapeutic impact of the timing of antiretroviral therapy in patients diagnosed with primary human immunodeficiency virus type 1 infection. Clin Infect Dis. 2018;66:1519-27.
Kosakovsky Pond S, Weaver S, Leigh Brown A, Wertheim O. HIV-TRACE (TRAnsmission Cluster Engine): a tool for large scale molecular epidemiology of HIV-1 and other rapidly evolving pathogens. Mol Biol Evol. 2018;35(7):1812-9.
Schreiber GB, Busch MP, Kleinman SH, Korelitz JJ. The risk of transfusion-transmitted viral infections. The Retrovirus Epidemiology Donor Study. N Engl J Med. 1996;334:1685-90.
Seed CR, Kiely P, Keller AJ. Residual risk of transfusion transmitted human immunodeficiency virus, hepatitis B virus, hepatitis C virus and human T lymphotrophic virus. Intern Med J. 2005;35:592-8.
Assal A, Barlet V, Deschaseaux M, Dupont I, Gallian P, Guitton C, et al. Sensitivity of two hepatitis B virus, hepatitis C virus (HCV), and human immunodeficiency virus (HIV) nucleic acid test systems relative to hepatitis B surface antigen, anti-HCV, anti-HIV, and p24/anti-HIV combination assays in seroconversion panels. Transfusion. 2009;49:301-10.
Pillonel J, Heraud-Bousquet V, Pelletier B, Semaille C, Velter A, Saura C, et al. Deferral from donating blood of men who have sex with men: impact on the risk of HIV transmission by transfusion in France. Vox Sang. 2012;102:13-21.
Cazein F, Lot F, Pillonel J, Le Strat Y, Sommen C, Pinget R, et al. New HIV and AIDS diagnoses, France, 2003-2012. Bull Epidémiol Hebd. 2014;154-62.
van de Laar TJ, Bezemer D, Van Laethem K, Vandewalle G, de Smet A, Van Wijngaerden E, et al. Phylogenetic evidence for underreporting of male-to-male sex among human immunodeficiency virus-infected donors in the Netherlands and Flanders. Transfusion. 2017;57:1235-47.
Hué S, Brown AE, Ragonnet-Cronin M, Lycett SJ, Dunn DT, Fearnhill E, et al. Phylogenetic analyses reveal HIV-1 infections between men misclassified as heterosexual transmissions. AIDS. 2014;28:1967-75.
Robineau O, Frange P, Barin F, Cazein F, Girard PM, Chaix ML, et al. Combining the estimated date of HIV infection with a phylogenetic cluster study to better understand HIV spread: application in a Paris neighbourhood. PLoS One. 2015;10:e0135367.
Ragonnet-Cronin M, Lycett SJ, Hodcroft EB, Hué S, Fearnhill E, Brown AE, et al. Transmission of non-B HIV subtypes in the United Kingdom is increasingly driven by large non-heterosexual transmission clusters. J Infect Dis. 2016;213:1410-8.
Novitsky V, Moyo S, Lei Q, DeGruttola V, Essex M. Impact of sampling density on the extent of HIV clustering. AIDS Res Hum Retroviruses. 2014;30:1226-35.