TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression.
angiogenesis
brain tumor
brain tumor microenvironment
brain tumor parenchyma
glioblastoma
glioma
microglia
myeloid cells
progenitor cells
rain
tumor-associated macrophages
Journal
Cell systems
ISSN: 2405-4720
Titre abrégé: Cell Syst
Pays: United States
ID NLM: 101656080
Informations de publication
Date de publication:
17 03 2021
17 03 2021
Historique:
received:
26
09
2019
revised:
07
04
2020
accepted:
04
01
2021
pubmed:
17
2
2021
medline:
15
12
2021
entrez:
16
2
2021
Statut:
ppublish
Résumé
Aggressive brain tumors like glioblastoma depend on support by their local environment and subsets of tumor parenchymal cells may promote specific phases of disease progression. We investigated the glioblastoma microenvironment with transgenic lineage-tracing models, intravital imaging, single-cell transcriptomics, immunofluorescence analysis as well as histopathology and characterized a previously unacknowledged population of tumor-associated cells with a myeloid-like expression profile (TAMEP) that transiently appeared during glioblastoma growth. TAMEP of mice and humans were identified with specific markers. Notably, TAMEP did not derive from microglia or peripheral monocytes but were generated by a fraction of CNS-resident, SOX2-positive progenitors. Abrogation of this progenitor cell population, by conditional Sox2-knockout, drastically reduced glioblastoma vascularization and size. Hence, TAMEP emerge as a tumor parenchymal component with a strong impact on glioblastoma progression.
Identifiants
pubmed: 33592194
pii: S2405-4712(21)00036-3
doi: 10.1016/j.cels.2021.01.002
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
248-262.e7Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.