Genetic regulation and heritability of miRNA and mRNA expression link to phosphorus utilization and gut microbiome.
heritability
mRNA-eQTL
miR-eQTL
microbiota
mineral homeostasis
phosphorus
Journal
Open biology
ISSN: 2046-2441
Titre abrégé: Open Biol
Pays: England
ID NLM: 101580419
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
entrez:
17
2
2021
pubmed:
18
2
2021
medline:
4
2
2022
Statut:
ppublish
Résumé
Improved utilization of phytates and mineral phosphorus (P) in monogastric animals contributes significantly to preserving the finite resource of mineral P and mitigating environmental pollution. In order to identify pathways and to prioritize candidate genes related to P utilization (PU), the genomic heritability of 77 and 80 trait-dependent expressed miRNAs and mRNAs in 482 Japanese quail were estimated and eQTL (expression quantitative trait loci) were detected. In total, 104 miR-eQTL (microRNA expression quantitative traits loci) were associated with SNP markers (false discovery rate less than 10%) including 41 eQTL of eight miRNAs. Similarly, 944 mRNA-eQTL were identified at the 5% False discovery rate threshold, with 573 being cis-eQTL of 36 mRNAs. High heritabilities of miRNA and mRNA expression coincide with highly significant eQTL. Integration of phenotypic data with transcriptome and microbiome data of the same animals revealed genetic regulated mRNA and miRNA transcripts (SMAD3, CAV1, ENNPP6, ATP2B4, miR-148a-3p, miR-146b-5p, miR-16-5p, miR-194, miR-215-5p, miR-199-3p, miR-1388a-3p) and microbes (
Identifiants
pubmed: 33593158
doi: 10.1098/rsob.200182
pmc: PMC8061690
doi:
Substances chimiques
Avian Proteins
0
MicroRNAs
0
RNA, Messenger
0
Phosphorus
27YLU75U4W
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
200182Références
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