Circulating RNA biomarkers in diffuse large B-cell lymphoma: a systematic review.
Biomarkers
DLBCL
Diffuse large B-cell lymphoma
Extracellular RNA
Liquid biopsy
Journal
Experimental hematology & oncology
ISSN: 2162-3619
Titre abrégé: Exp Hematol Oncol
Pays: England
ID NLM: 101590676
Informations de publication
Date de publication:
16 Feb 2021
16 Feb 2021
Historique:
received:
30
12
2020
accepted:
06
02
2021
entrez:
17
2
2021
pubmed:
18
2
2021
medline:
18
2
2021
Statut:
epublish
Résumé
Diffuse large B-cell lymphoma (DLBCL) is the most common histological subtype of non-Hodgkin's lymphomas (NHL). DLBCL is an aggressive malignancy that displays a great heterogeneity in terms of morphology, genetics and biological behavior. While a sustained complete remission is obtained in the majority of patients with standard immunochemotherapy, patients with refractory of relapsed disease after first-line treatment have a poor prognosis. This patient group represents an important unmet need in lymphoma treatment. In recent years, improved understanding of the underlying molecular pathogenesis had led to new classification and prognostication tools, including the development of cell-free biomarkers in liquid biopsies. Although the majority of studies have focused on the use of cell-free fragments of DNA (cfDNA), there has been an increased interest in circulating-free coding and non-coding RNA, including messenger RNA (mRNA), microRNA (miRNA), long non-coding RNA (lncRNA) and circular RNA (circRNA), as well as RNA encapsulated in extracellular vesicles or tumor-educated platelets (TEPs). We performed a systematic search in PubMed to identify articles that evaluated circulating RNA as diagnostic, subtype, treatment response or prognostic biomarkers in a human DLBCL population. A total of 35 articles met the inclusion criteria. The aim of this systematic review is to present the current understanding of circulating RNA molecules as biomarker in DLBCL and to discuss their future potential.
Identifiants
pubmed: 33593440
doi: 10.1186/s40164-021-00208-3
pii: 10.1186/s40164-021-00208-3
pmc: PMC7885416
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
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