Depot medroxyprogesterone acetate (DMPA) enhances susceptibility and increases the window of vulnerability to HIV-1 in humanized mice.
Animals
Contraceptive Agents, Hormonal
/ adverse effects
Cytokines
/ metabolism
Delayed-Action Preparations
Disease Susceptibility
/ chemically induced
Female
HIV-1
Host-Pathogen Interactions
/ drug effects
Humans
Infant, Newborn
Macrophages
Medroxyprogesterone Acetate
/ adverse effects
Mice
Mice, Inbred C57BL
Vagina
/ drug effects
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
16 02 2021
16 02 2021
Historique:
received:
20
07
2020
accepted:
27
01
2021
entrez:
17
2
2021
pubmed:
18
2
2021
medline:
30
12
2021
Statut:
epublish
Résumé
The progestin-based hormonal contraceptive Depot Medroxyprogesterone Acetate (DMPA) is widely used in sub-Saharan Africa, where HIV-1 is endemic. Meta-analyses have shown that women using DMPA are 40% more likely than women not using hormonal contraceptives to acquire Human Immunodeficiency Virus (HIV-1). Therefore understanding how DMPA increases susceptibility to HIV-1 is an important public health issue. Using C57BL/6 mice and our previously optimized humanized mouse model (NOD-Rag1
Identifiants
pubmed: 33594113
doi: 10.1038/s41598-021-83242-9
pii: 10.1038/s41598-021-83242-9
pmc: PMC7887257
doi:
Substances chimiques
Contraceptive Agents, Hormonal
0
Cytokines
0
Delayed-Action Preparations
0
Medroxyprogesterone Acetate
C2QI4IOI2G
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3894Subventions
Organisme : CIHR
ID : FRN#126019
Pays : Canada
Organisme : CIHR
ID : FRN#138657
Pays : Canada
Références
Mucosal Immunol. 2016 Nov;9(6):1571-1583
pubmed: 27007679
J Am Assoc Lab Anim Sci. 2014 Nov;53(6):700-7
pubmed: 25650978
J Med Primatol. 2015 Oct;44(5):286-95
pubmed: 26238265
Afr J Reprod Health. 2012 Dec;16(4):68-80
pubmed: 23444545
Hum Reprod. 2015 Apr;30(4):925-36
pubmed: 25662808
Lancet Infect Dis. 2016 Apr;16(4):441-8
pubmed: 26723758
Dis Model Mech. 2019 Oct 23;12(10):
pubmed: 31537512
J Reprod Immunol. 2011 Mar;88(2):204-9
pubmed: 21296427
Reproduction. 2007 May;133(5):1035-44
pubmed: 17616732
Nat Rev Immunol. 2008 Jun;8(6):447-57
pubmed: 18469831
Virology. 2006 Aug 15;352(1):169-77
pubmed: 16730772
J Med Primatol. 2015 Oct;44(5):301-5
pubmed: 26054016
Mucosal Immunol. 2017 Sep;10(5):1270-1278
pubmed: 28051087
AIDS Res Hum Retroviruses. 2013 Mar;29(3):592-601
pubmed: 23189932
Nat Med. 1996 Oct;2(10):1084-9
pubmed: 8837605
PLoS Med. 2015 Jan 22;12(1):e1001778
pubmed: 25612136
Curr Protoc Neurosci. 2009 Jul;Appendix 4:Appendix 4I
pubmed: 19575469
J Med Primatol. 2007 Aug;36(4-5):266-75
pubmed: 17669215
J Virol. 2015 Sep;89(17):8793-805
pubmed: 26085144
Sci Rep. 2017 Nov 10;7(1):15263
pubmed: 29127409
Mucosal Immunol. 2013 Jan;6(1):56-68
pubmed: 22718264
AIDS. 2016 Nov 13;30(17):2665-2683
pubmed: 27500670
PLoS One. 2012;7(4):e35538
pubmed: 22514749
Endocr Rev. 2018 Feb 1;39(1):36-78
pubmed: 29309550
AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S119-23
pubmed: 9581895
J Virol. 2003 Sep;77(18):9845-51
pubmed: 12941893
Int J STD AIDS. 2011 Jul;22(7):373-5
pubmed: 21729954
Mucosal Immunol. 2013 Nov;6(6):1081-90
pubmed: 23385427
Sex Transm Dis. 2015 Dec;42(12):694-701
pubmed: 26562699
PLoS Pathog. 2010 Apr 08;6(4):e1000852
pubmed: 20386714
Lancet Infect Dis. 2012 Jan;12(1):19-26
pubmed: 21975269
PLoS Pathog. 2016 Sep 22;12(9):e1005885
pubmed: 27658293
J Acquir Immune Defic Syndr. 2016 Aug 1;72(4):363-71
pubmed: 27355414
J Int AIDS Soc. 2018 Jan;21(1):
pubmed: 29334191
PLoS One. 2013 Apr 17;8(4):e62069
pubmed: 23614015
J Acquir Immune Defic Syndr. 2011 Aug 1;57(4):261-4
pubmed: 21546848
J Infect Dis. 2004 Nov 1;190(9):1697-705
pubmed: 15478078
AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S125-30
pubmed: 9581896